Lau A - Search Results

1

ATM kinase inhibition preferentially sensitizes p53-mutant glioma to ionizing radiation.

Biddlestone-Thorpe L, Sajjad M, Rosenberg E, Beckta JM, Valerie NC, Tokarz M, Adams BR, Wagner AF, Khalil A, Gilfor D, Golding SE, Deb S, Temesi DG, Lau A, O'Connor MJ, Choe KS, Parada LF, Lim SK, Mukhopadhyay ND, Valerie K. Biddlestone-Thorpe L, et al. Among authors: lau a. Clin Cancer Res. 2013 Jun 15;19(12):3189-200. doi: 10.1158/1078-0432.CCR-12-3408. Epub 2013 Apr 25. Clin Cancer Res. 2013. PMID: 23620409 Free PMC article.

2

Suppression of retroviral infection by the RAD52 DNA repair protein.

Lau A, Kanaar R, Jackson SP, O'Connor MJ. Lau A, et al. EMBO J. 2004 Aug 18;23(16):3421-9. doi: 10.1038/sj.emboj.7600348. Epub 2004 Aug 5. EMBO J. 2004. PMID: 15297876 Free PMC article.

3

The overexpression of specialized DNA polymerases in cancer.

Albertella MR, Lau A, O'Connor MJ. Albertella MR, et al. Among authors: lau a. DNA Repair (Amst). 2005 May 2;4(5):583-93. doi: 10.1016/j.dnarep.2005.01.005. DNA Repair (Amst). 2005. PMID: 15811630

4

Suppression of HIV-1 infection by a small molecule inhibitor of the ATM kinase.

Lau A, Swinbank KM, Ahmed PS, Taylor DL, Jackson SP, Smith GC, O'Connor MJ. Lau A, et al. Nat Cell Biol. 2005 May;7(5):493-500. doi: 10.1038/ncb1250. Epub 2005 Apr 17. Nat Cell Biol. 2005. PMID: 15834407

5

Selective inhibition of BRCA2-deficient mammary tumor cell growth by AZD2281 and cisplatin.

Evers B, Drost R, Schut E, de Bruin M, van der Burg E, Derksen PW, Holstege H, Liu X, van Drunen E, Beverloo HB, Smith GC, Martin NM, Lau A, O'Connor MJ, Jonkers J. Evers B, et al. Among authors: lau a. Clin Cancer Res. 2008 Jun 15;14(12):3916-25. doi: 10.1158/1078-0432.CCR-07-4953. Clin Cancer Res. 2008. PMID: 18559613 Free article.

6

Poly(ADP-ribose) polymerase-1 inhibitor treatment regresses autochthonous Brca2/p53-mutant mammary tumors in vivo and delays tumor relapse in combination with carboplatin.

Hay T, Matthews JR, Pietzka L, Lau A, Cranston A, Nygren AO, Douglas-Jones A, Smith GC, Martin NM, O'Connor M, Clarke AR. Hay T, et al. Among authors: lau a. Cancer Res. 2009 May 1;69(9):3850-5. doi: 10.1158/0008-5472.CAN-08-2388. Epub 2009 Apr 21. Cancer Res. 2009. PMID: 19383921

7

Tumor growth inhibition by olaparib in BRCA2 germline-mutated patient-derived ovarian cancer tissue xenografts.

Kortmann U, McAlpine JN, Xue H, Guan J, Ha G, Tully S, Shafait S, Lau A, Cranston AN, O'Connor MJ, Huntsman DG, Wang Y, Gilks CB. Kortmann U, et al. Among authors: lau a. Clin Cancer Res. 2011 Feb 15;17(4):783-91. doi: 10.1158/1078-0432.CCR-10-1382. Epub 2010 Nov 19. Clin Cancer Res. 2011. PMID: 21097693

8

Evaluation of candidate biomarkers to predict cancer cell sensitivity or resistance to PARP-1 inhibitor treatment.

Oplustilova L, Wolanin K, Mistrik M, Korinkova G, Simkova D, Bouchal J, Lenobel R, Bartkova J, Lau A, O'Connor MJ, Lukas J, Bartek J. Oplustilova L, et al. Among authors: lau a. Cell Cycle. 2012 Oct 15;11(20):3837-50. doi: 10.4161/cc.22026. Epub 2012 Sep 14. Cell Cycle. 2012. PMID: 22983061 Free PMC article.

9

Loss of 53BP1 causes PARP inhibitor resistance in Brca1-mutated mouse mammary tumors.

Jaspers JE, Kersbergen A, Boon U, Sol W, van Deemter L, Zander SA, Drost R, Wientjens E, Ji J, Aly A, Doroshow JH, Cranston A, Martin NM, Lau A, O'Connor MJ, Ganesan S, Borst P, Jonkers J, Rottenberg S. Jaspers JE, et al. Among authors: lau a. Cancer Discov. 2013 Jan;3(1):68-81. doi: 10.1158/2159-8290.CD-12-0049. Epub 2012 Oct 25. Cancer Discov. 2013. PMID: 23103855 Free PMC article.

10

Preclinical evaluation of a novel ATM inhibitor, KU59403, in vitro and in vivo in p53 functional and dysfunctional models of human cancer.

Batey MA, Zhao Y, Kyle S, Richardson C, Slade A, Martin NM, Lau A, Newell DR, Curtin NJ. Batey MA, et al. Among authors: lau a. Mol Cancer Ther. 2013 Jun;12(6):959-67. doi: 10.1158/1535-7163.MCT-12-0707. Epub 2013 Mar 19. Mol Cancer Ther. 2013. PMID: 23512991 Free PMC article.

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