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Restoring p53 function in human melanoma cells by inhibiting MDM2 and cyclin B1/CDK1-phosphorylated nuclear iASPP.
Lu M, Breyssens H, Salter V, Zhong S, Hu Y, Baer C, Ratnayaka I, Sullivan A, Brown NR, Endicott J, Knapp S, Kessler BM, Middleton MR, Siebold C, Jones EY, Sviderskaya EV, Cebon J, John T, Caballero OL, Goding CR, Lu X. Lu M, et al. Among authors: lu x. Cancer Cell. 2013 May 13;23(5):618-33. doi: 10.1016/j.ccr.2013.03.013. Epub 2013 Apr 25. Cancer Cell. 2013. PMID: 23623661 Free article.
Nuclear iASPP may facilitate prostate cancer progression.
Morris EV, Cerundolo L, Lu M, Verrill C, Fritzsche F, White MJ, Thalmann GN, ten Donkelaar CS, Ratnayaka I, Salter V, Hamdy FC, Lu X, Bryant RJ. Morris EV, et al. Among authors: lu x, lu m. Cell Death Dis. 2014 Oct 23;5(10):e1492. doi: 10.1038/cddis.2014.442. Cell Death Dis. 2014. PMID: 25341046 Free PMC article.
iASPP, a previously unidentified regulator of desmosomes, prevents arrhythmogenic right ventricular cardiomyopathy (ARVC)-induced sudden death.
Notari M, Hu Y, Sutendra G, Dedeić Z, Lu M, Dupays L, Yavari A, Carr CA, Zhong S, Opel A, Tinker A, Clarke K, Watkins H, Ferguson DJ, Kelsell DP, de Noronha S, Sheppard MN, Hollinshead M, Mohun TJ, Lu X. Notari M, et al. Among authors: lu x, lu m. Proc Natl Acad Sci U S A. 2015 Mar 3;112(9):E973-81. doi: 10.1073/pnas.1408111112. Epub 2015 Feb 17. Proc Natl Acad Sci U S A. 2015. PMID: 25691752 Free PMC article.
Restoring p53 Function in Human Melanoma Cells by Inhibiting MDM2 and Cyclin B1/CDK1-Phosphorylated Nuclear iASPP.
Lu M, Breyssens H, Salter V, Zhong S, Hu Y, Baer C, Ratnayaka I, Sullivan A, Brown NR, Endicott J, Knapp S, Kessler BM, Middleton MR, Siebold C, Jones EY, Sviderskaya EV, Cebon J, John T, Caballero OL, Goding CR, Lu X. Lu M, et al. Among authors: lu x. Cancer Cell. 2016 Nov 14;30(5):822-823. doi: 10.1016/j.ccell.2016.09.019. Cancer Cell. 2016. PMID: 27846394 Free article. No abstract available.
iASPP mediates p53 selectivity through a modular mechanism fine-tuning DNA recognition.
Chen S, Wu J, Zhong S, Li Y, Zhang P, Ma J, Ren J, Tan Y, Wang Y, Au KF, Siebold C, Bond GL, Chen Z, Lu M, Jones EY, Lu X. Chen S, et al. Among authors: lu x, lu m. Proc Natl Acad Sci U S A. 2019 Aug 27;116(35):17470-17479. doi: 10.1073/pnas.1909393116. Epub 2019 Aug 8. Proc Natl Acad Sci U S A. 2019. PMID: 31395738 Free PMC article.
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