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The TLR4 antagonist Eritoran protects mice from lethal influenza infection.
Shirey KA, Lai W, Scott AJ, Lipsky M, Mistry P, Pletneva LM, Karp CL, McAlees J, Gioannini TL, Weiss J, Chen WH, Ernst RK, Rossignol DP, Gusovsky F, Blanco JC, Vogel SN. Shirey KA, et al. Among authors: gioannini tl. Nature. 2013 May 23;497(7450):498-502. doi: 10.1038/nature12118. Epub 2013 May 1. Nature. 2013. PMID: 23636320 Free PMC article.
Respiratory syncytial virus fusion protein-induced toll-like receptor 4 (TLR4) signaling is inhibited by the TLR4 antagonists Rhodobacter sphaeroides lipopolysaccharide and eritoran (E5564) and requires direct interaction with MD-2.
Rallabhandi P, Phillips RL, Boukhvalova MS, Pletneva LM, Shirey KA, Gioannini TL, Weiss JP, Chow JC, Hawkins LD, Vogel SN, Blanco JC. Rallabhandi P, et al. Among authors: gioannini tl. mBio. 2012 Aug 7;3(4):e00218-12. doi: 10.1128/mBio.00218-12. Print 2012. mBio. 2012. PMID: 22872782 Free PMC article.
71 results