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Page 1
Nonsteroidal glucocorticoid agonists: tetrahydronaphthalenes with alternative steroidal A-ring mimetics possessing dissociated (transrepression/transactivation) efficacy selectivity.
Biggadike K, Boudjelal M, Clackers M, Coe DM, Demaine DA, Hardy GW, Humphreys D, Inglis GG, Johnston MJ, Jones HT, House D, Loiseau R, Needham D, Skone PA, Uings I, Veitch G, Weingarten GG, McLay IM, Macdonald SJ. Biggadike K, et al. Among authors: needham d. J Med Chem. 2007 Dec 27;50(26):6519-34. doi: 10.1021/jm070778w. Epub 2007 Nov 27. J Med Chem. 2007. PMID: 18038970
Discovery of a rapidly metabolized, long-acting β(2) adrenergic receptor agonist with a short onset time incorporating a sulfone group suitable for once-daily dosing.
Procopiou PA, Barrett VJ, Biggadike K, Butchers PR, Craven A, Ford AJ, Guntrip SB, Holmes DS, Hughes SC, Jones AE, Looker BE, Mutch PJ, Ruston M, Needham D, Smith CE. Procopiou PA, et al. Among authors: needham d. J Med Chem. 2014 Jan 9;57(1):159-70. doi: 10.1021/jm401532g. Epub 2013 Dec 20. J Med Chem. 2014. PMID: 24359185
Investigation of Janus Kinase (JAK) Inhibitors for Lung Delivery and the Importance of Aldehyde Oxidase Metabolism.
Wellaway CR, Baldwin IR, Bamborough P, Barker D, Bartholomew MA, Chung CW, Dümpelfeld B, Evans JP, Fazakerley NJ, Homes P, Keeling SP, Lewell XQ, McNab FW, Morley J, Needham D, Neu M, van Oosterhout AJM, Pal A, Reinhard FBM, Rianjongdee F, Robertson CM, Rowland P, Shah RR, Sherriff EB, Sloan LA, Teague S, Thomas DA, Wellaway N, Wojno-Picon J, Woolven JM, Coe DM. Wellaway CR, et al. Among authors: needham d. J Med Chem. 2022 Jan 13;65(1):633-664. doi: 10.1021/acs.jmedchem.1c01765. Epub 2021 Dec 20. J Med Chem. 2022. PMID: 34928601
Synthesis and structure-activity relationships of indazole arylsulfonamides as allosteric CC-chemokine receptor 4 (CCR4) antagonists.
Procopiou PA, Barrett JW, Barton NP, Begg M, Clapham D, Copley RC, Ford AJ, Graves RH, Hall DA, Hancock AP, Hill AP, Hobbs H, Hodgson ST, Jumeaux C, Lacroix YM, Miah AH, Morriss KM, Needham D, Sheriff EB, Slack RJ, Smith CE, Sollis SL, Staton H. Procopiou PA, et al. Among authors: needham d. J Med Chem. 2013 Mar 14;56(5):1946-60. doi: 10.1021/jm301572h. Epub 2013 Feb 27. J Med Chem. 2013. PMID: 23409871
Tetrahydroisoquinolines affect the whole-cell phenotype of Mycobacterium tuberculosis by inhibiting the ATP-dependent MurE ligase.
Guzman JD, Pesnot T, Barrera DA, Davies HM, McMahon E, Evangelopoulos D, Mortazavi PN, Munshi T, Maitra A, Lamming ED, Angell R, Gershater MC, Redmond JM, Needham D, Ward JM, Cuca LE, Hailes HC, Bhakta S. Guzman JD, et al. Among authors: needham d. J Antimicrob Chemother. 2015;70(6):1691-703. doi: 10.1093/jac/dkv010. Epub 2015 Feb 4. J Antimicrob Chemother. 2015. PMID: 25656411 Free PMC article.
The south-east Scotland dermatology workload study: 30 years' analysis.
Holme SA, Scott-Lang VE, Ooi ET, Matthews AG, Darling MI, Needham D, McCormack SK. Holme SA, et al. Among authors: needham d. Br J Dermatol. 2012 Jul;167(1):123-30. doi: 10.1111/j.1365-2133.2012.10906.x. Epub 2012 Jun 1. Br J Dermatol. 2012. PMID: 22372993
Effect of the COVID-19 pandemic on unmet healthcare needs after hospital discharge in acute respiratory failure survivors: A multicenter prospective cohort study.
Carmichael HL, Groat D, Dinglas VD, Bose S, Kasimov MM, Jackson JC, Kadiri NP, Trejo-Zambrano MI, Sevin CM, Green T, Needham DM, Brown SM; APICS‐COVID Study Team. Carmichael HL, et al. Among authors: needham dm. J Hosp Med. 2024 Dec 19. doi: 10.1002/jhm.13576. Online ahead of print. J Hosp Med. 2024. PMID: 39702942
669 results