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Diaryltriazine non-nucleoside reverse transcriptase inhibitors are potent candidates for pre-exposure prophylaxis in the prevention of sexual HIV transmission.
Ariën KK, Venkatraj M, Michiels J, Joossens J, Vereecken K, Van der Veken P, Abdellati S, Cuylaerts V, Crucitti T, Heyndrickx L, Heeres J, Augustyns K, Lewi PJ, Vanham G. Ariën KK, et al. Among authors: vanham g. J Antimicrob Chemother. 2013 Sep;68(9):2038-47. doi: 10.1093/jac/dkt166. Epub 2013 May 3. J Antimicrob Chemother. 2013. PMID: 23645585
A series of diaryltriazines and diarylpyrimidines are highly potent nonnucleoside reverse transcriptase inhibitors with possible applications as microbicides.
Van Herrewege Y, Vanham G, Michiels J, Fransen K, Kestens L, Andries K, Janssen P, Lewi P. Van Herrewege Y, et al. Among authors: vanham g. Antimicrob Agents Chemother. 2004 Oct;48(10):3684-9. doi: 10.1128/AAC.48.10.3684-3689.2004. Antimicrob Agents Chemother. 2004. PMID: 15388420 Free PMC article.
In vitro evaluation of viability, integrity, and inflammation in genital epithelia upon exposure to pharmaceutical excipients and candidate microbicides.
Gali Y, Delezay O, Brouwers J, Addad N, Augustijns P, Bourlet T, Hamzeh-Cognasse H, Ariën KK, Pozzetto B, Vanham G. Gali Y, et al. Among authors: vanham g. Antimicrob Agents Chemother. 2010 Dec;54(12):5105-14. doi: 10.1128/AAC.00456-10. Epub 2010 Oct 4. Antimicrob Agents Chemother. 2010. PMID: 20921308 Free PMC article.
Human immunodeficiency virus type 1 resistance or cross-resistance to nonnucleoside reverse transcriptase inhibitors currently under development as microbicides.
Selhorst P, Vazquez AC, Terrazas-Aranda K, Michiels J, Vereecken K, Heyndrickx L, Weber J, Quiñones-Mateu ME, Ariën KK, Vanham G. Selhorst P, et al. Among authors: vanham g. Antimicrob Agents Chemother. 2011 Apr;55(4):1403-13. doi: 10.1128/AAC.01426-10. Epub 2011 Jan 31. Antimicrob Agents Chemother. 2011. PMID: 21282453 Free PMC article.
HIV sexual transmission and microbicides.
Ariën KK, Jespers V, Vanham G. Ariën KK, et al. Among authors: vanham g. Rev Med Virol. 2011 Mar;21(2):110-33. doi: 10.1002/rmv.684. Epub 2011 Mar 15. Rev Med Virol. 2011. PMID: 21412935 Review.
Novel diarylpyridinones, diarylpyridazinones and diarylphthalazinones as potential HIV-1 nonnucleoside reverse transcriptase inhibitors (NNRTIs).
Venkatraj M, Ariën KK, Heeres J, Dirié B, Joossens J, Van Goethem S, Van der Veken P, Michiels J, Vande Velde CM, Vanham G, Lewi PJ, Augustyns K. Venkatraj M, et al. Among authors: vanham g. Bioorg Med Chem. 2011 Oct 15;19(20):5924-34. doi: 10.1016/j.bmc.2011.08.060. Epub 2011 Sep 1. Bioorg Med Chem. 2011. PMID: 21930388
In vitro activities of candidate microbicides against cell-associated HIV.
Selhorst P, Grupping K, Bourlet T, Delézay O, Ariën KK, Vanham G. Selhorst P, et al. Among authors: vanham g. Antimicrob Agents Chemother. 2012 Feb;56(2):805-15. doi: 10.1128/AAC.05801-11. Epub 2011 Nov 14. Antimicrob Agents Chemother. 2012. PMID: 22083472 Free PMC article.
Reverse transcriptase inhibitors as microbicides.
Lewi P, Heeres J, Ariën K, Venkatraj M, Joossens J, Van der Veken P, Augustyns K, Vanham G. Lewi P, et al. Among authors: vanham g. Curr HIV Res. 2012 Jan 1;10(1):27-35. doi: 10.2174/157016212799304643. Curr HIV Res. 2012. PMID: 22264043 Review.
202 results