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Propafenone blocks human cardiac Kir2.x channels by decreasing the negative electrostatic charge in the cytoplasmic pore.
Amorós I, Dolz-Gaitón P, Gómez R, Matamoros M, Barana A, de la Fuente MG, Núñez M, Pérez-Hernández M, Moraleda I, Gálvez E, Iriepa I, Tamargo J, Caballero R, Delpón E. Amorós I, et al. Among authors: gomez r. Biochem Pharmacol. 2013 Jul 15;86(2):267-78. doi: 10.1016/j.bcp.2013.04.023. Epub 2013 May 3. Biochem Pharmacol. 2013. PMID: 23648307
Pharmacology of cardiac potassium channels.
Tamargo J, Caballero R, Gómez R, Valenzuela C, Delpón E. Tamargo J, et al. Among authors: gomez r. Cardiovasc Res. 2004 Apr 1;62(1):9-33. doi: 10.1016/j.cardiores.2003.12.026. Cardiovasc Res. 2004. PMID: 15023549 Review.
Flecainide increases Kir2.1 currents by interacting with cysteine 311, decreasing the polyamine-induced rectification.
Caballero R, Dolz-Gaitón P, Gómez R, Amorós I, Barana A, González de la Fuente M, Osuna L, Duarte J, López-Izquierdo A, Moraleda I, Gálvez E, Sánchez-Chapula JA, Tamargo J, Delpón E. Caballero R, et al. Among authors: gomez r. Proc Natl Acad Sci U S A. 2010 Aug 31;107(35):15631-6. doi: 10.1073/pnas.1004021107. Epub 2010 Aug 16. Proc Natl Acad Sci U S A. 2010. PMID: 20713726 Free PMC article.
Functional effects of a missense mutation in HERG associated with type 2 long QT syndrome.
Amorós I, Jiménez-Jáimez J, Tercedor L, Barana A, Gómez R, de la Fuente MG, Dolz-Gaitón P, Alvarez M, Martínez-Espín E, Lorente JA, Melgares R, Tamargo J, Delpón E, Caballero R. Amorós I, et al. Among authors: gomez r. Heart Rhythm. 2011 Mar;8(3):463-70. doi: 10.1016/j.hrthm.2010.11.032. Epub 2010 Nov 23. Heart Rhythm. 2011. PMID: 21109023
3,147 results