Lehtinen MJ - Search Results

1

Structural basis for complement evasion by Lyme disease pathogen Borrelia burgdorferi.

Bhattacharjee A, Oeemig JS, Kolodziejczyk R, Meri T, Kajander T, Lehtinen MJ, Iwaï H, Jokiranta TS, Goldman A. Bhattacharjee A, et al. Among authors: lehtinen mj. J Biol Chem. 2013 Jun 28;288(26):18685-95. doi: 10.1074/jbc.M113.459040. Epub 2013 May 8. J Biol Chem. 2013. PMID: 23658013 Free PMC article.

2

Structure of complement factor H carboxyl-terminus reveals molecular basis of atypical haemolytic uremic syndrome.

Jokiranta TS, Jaakola VP, Lehtinen MJ, Pärepalo M, Meri S, Goldman A. Jokiranta TS, et al. Among authors: lehtinen mj. EMBO J. 2006 Apr 19;25(8):1784-94. doi: 10.1038/sj.emboj.7601052. Epub 2006 Apr 6. EMBO J. 2006. PMID: 16601698 Free PMC article.

3

Mutations of factor H impair regulation of surface-bound C3b by three mechanisms in atypical hemolytic uremic syndrome.

Lehtinen MJ, Rops AL, Isenman DE, van der Vlag J, Jokiranta TS. Lehtinen MJ, et al. J Biol Chem. 2009 Jun 5;284(23):15650-8. doi: 10.1074/jbc.M900814200. Epub 2009 Apr 7. J Biol Chem. 2009. PMID: 19351878 Free PMC article.

4

Both domain 19 and domain 20 of factor H are involved in binding to complement C3b and C3d.

Bhattacharjee A, Lehtinen MJ, Kajander T, Goldman A, Jokiranta TS. Bhattacharjee A, et al. Among authors: lehtinen mj. Mol Immunol. 2010 May;47(9):1686-91. doi: 10.1016/j.molimm.2010.03.007. Epub 2010 Apr 7. Mol Immunol. 2010. PMID: 20378178

5

Dual interaction of factor H with C3d and glycosaminoglycans in host-nonhost discrimination by complement.

Kajander T, Lehtinen MJ, Hyvärinen S, Bhattacharjee A, Leung E, Isenman DE, Meri S, Goldman A, Jokiranta TS. Kajander T, et al. Among authors: lehtinen mj. Proc Natl Acad Sci U S A. 2011 Feb 15;108(7):2897-902. doi: 10.1073/pnas.1017087108. Epub 2011 Feb 1. Proc Natl Acad Sci U S A. 2011. PMID: 21285368 Free PMC article.

6

Mutations in Complement Factor H Impair Alternative Pathway Regulation on Mouse Glomerular Endothelial Cells in Vitro.

Loeven MA, Rops AL, Lehtinen MJ, van Kuppevelt TH, Daha MR, Smith RJ, Bakker M, Berden JH, Rabelink TJ, Jokiranta TS, van der Vlag J. Loeven MA, et al. Among authors: lehtinen mj. J Biol Chem. 2016 Mar 4;291(10):4974-81. doi: 10.1074/jbc.M115.702506. Epub 2016 Jan 4. J Biol Chem. 2016. PMID: 26728463 Free PMC article.

7

The group B streptococcal beta and pneumococcal Hic proteins are structurally related immune evasion molecules that bind the complement inhibitor factor H in an analogous fashion.

Jarva H, Hellwage J, Jokiranta TS, Lehtinen MJ, Zipfel PF, Meri S. Jarva H, et al. Among authors: lehtinen mj. J Immunol. 2004 Mar 1;172(5):3111-8. doi: 10.4049/jimmunol.172.5.3111. J Immunol. 2004. PMID: 14978117

8

Interdomain contact regions and angles between adjacent short consensus repeat domains.

Lehtinen MJ, Meri S, Jokiranta TS. Lehtinen MJ, et al. J Mol Biol. 2004 Dec 10;344(5):1385-96. doi: 10.1016/j.jmb.2004.10.017. J Mol Biol. 2004. PMID: 15561150

9

Microbes bind complement inhibitor factor H via a common site.

Meri T, Amdahl H, Lehtinen MJ, Hyvärinen S, McDowell JV, Bhattacharjee A, Meri S, Marconi R, Goldman A, Jokiranta TS. Meri T, et al. Among authors: lehtinen mj. PLoS Pathog. 2013;9(4):e1003308. doi: 10.1371/journal.ppat.1003308. Epub 2013 Apr 18. PLoS Pathog. 2013. PMID: 23637600 Free PMC article.

10

Y402H polymorphism of complement factor H affects binding affinity to C-reactive protein.

Laine M, Jarva H, Seitsonen S, Haapasalo K, Lehtinen MJ, Lindeman N, Anderson DH, Johnson PT, Järvelä I, Jokiranta TS, Hageman GS, Immonen I, Meri S. Laine M, et al. Among authors: lehtinen mj. J Immunol. 2007 Mar 15;178(6):3831-6. doi: 10.4049/jimmunol.178.6.3831. J Immunol. 2007. PMID: 17339482 Free PMC article. Clinical Trial.

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