Banner DW - Search Results

1

Optimization of triazine nitriles as rhodesain inhibitors: structure-activity relationships, bioisosteric imidazopyridine nitriles, and X-ray crystal structure analysis with human cathepsin L.

Ehmke V, Winkler E, Banner DW, Haap W, Schweizer WB, Rottmann M, Kaiser M, Freymond C, Schirmeister T, Diederich F. Ehmke V, et al. Among authors: banner dw. ChemMedChem. 2013 Jun;8(6):967-75. doi: 10.1002/cmdc.201300112. Epub 2013 May 9. ChemMedChem. 2013. PMID: 23658062

2

Repurposing a Library of Human Cathepsin L Ligands: Identification of Macrocyclic Lactams as Potent Rhodesain and Trypanosoma brucei Inhibitors.

Giroud M, Dietzel U, Anselm L, Banner D, Kuglstatter A, Benz J, Blanc JB, Gaufreteau D, Liu H, Lin X, Stich A, Kuhn B, Schuler F, Kaiser M, Brun R, Schirmeister T, Kisker C, Diederich F, Haap W. Giroud M, et al. J Med Chem. 2018 Apr 26;61(8):3350-3369. doi: 10.1021/acs.jmedchem.7b01869. Epub 2018 Apr 13. J Med Chem. 2018. PMID: 29590750

3

Halogen bonding at the active sites of human cathepsin L and MEK1 kinase: efficient interactions in different environments.

Hardegger LA, Kuhn B, Spinnler B, Anselm L, Ecabert R, Stihle M, Gsell B, Thoma R, Diez J, Benz J, Plancher JM, Hartmann G, Isshiki Y, Morikami K, Shimma N, Haap W, Banner DW, Diederich F. Hardegger LA, et al. Among authors: banner dw. ChemMedChem. 2011 Nov 4;6(11):2048-54. doi: 10.1002/cmdc.201100353. Epub 2011 Sep 6. ChemMedChem. 2011. PMID: 21898833

4

Mapping the fluorophilicity of a hydrophobic pocket: synthesis and biological evaluation of tricyclic thrombin inhibitors directing fluorinated alkyl groups into the p pocket.

Hoffmann-Röder A, Schweizer E, Egger J, Seiler P, Obst-Sander U, Wagner B, Kansy M, Banner DW, Diederich F. Hoffmann-Röder A, et al. Among authors: banner dw. ChemMedChem. 2006 Nov;1(11):1205-15. doi: 10.1002/cmdc.200600124. ChemMedChem. 2006. PMID: 17001711

5

Molecular recognition at the active site of factor Xa: cation-π interactions, stacking on planar peptide surfaces, and replacement of structural water.

Salonen LM, Holland MC, Kaib PS, Haap W, Benz J, Mary JL, Kuster O, Schweizer WB, Banner DW, Diederich F. Salonen LM, et al. Among authors: banner dw. Chemistry. 2012 Jan 2;18(1):213-22. doi: 10.1002/chem.201102571. Epub 2011 Dec 9. Chemistry. 2012. PMID: 22162109

6

Molecular recognition at the thrombin active site: structure-based design and synthesis of potent and selective thrombin inhibitors and the X-ray crystal structures of two thrombin-inhibitor complexes.

Obst U, Banner DW, Weber L, Diederich F. Obst U, et al. Among authors: banner dw. Chem Biol. 1997 Apr;4(4):287-95. doi: 10.1016/s1074-5521(97)90072-7. Chem Biol. 1997. PMID: 9195869

7

Fluorine interactions at the thrombin active site: protein backbone fragments H-C(alpha)-C=O comprise a favorable C-F environment and interactions of C-F with electrophiles.

Olsen JA, Banner DW, Seiler P, Wagner B, Tschopp T, Obst-Sander U, Kansy M, Müller K, Diederich F. Olsen JA, et al. Among authors: banner dw. Chembiochem. 2004 May 3;5(5):666-75. doi: 10.1002/cbic.200300907. Chembiochem. 2004. PMID: 15122639

8

Multipolar interactions in the D pocket of thrombin: large differences between tricyclic imide and lactam inhibitors.

Schweizer E, Hoffmann-Röder A, Olsen JA, Seiler P, Obst-Sander U, Wagner B, Kansy M, Banner DW, Diederich F. Schweizer E, et al. Among authors: banner dw. Org Biomol Chem. 2006 Jun 21;4(12):2364-75. doi: 10.1039/b602585d. Epub 2006 May 10. Org Biomol Chem. 2006. PMID: 16763681

9

Cation-pi interactions at the active site of factor Xa: dramatic enhancement upon stepwise N-alkylation of ammonium ions.

Salonen LM, Bucher C, Banner DW, Haap W, Mary JL, Benz J, Kuster O, Seiler P, Schweizer WB, Diederich F. Salonen LM, et al. Among authors: banner dw. Angew Chem Int Ed Engl. 2009;48(4):811-4. doi: 10.1002/anie.200804695. Angew Chem Int Ed Engl. 2009. PMID: 19101972 No abstract available.

10

A fluorine scan of thrombin inhibitors to map the fluorophilicity/fluorophobicity of an enzyme active site: evidence for C-F...C=O interactions.

Olsen JA, Banner DW, Seiler P, Obst Sander U, D'Arcy A, Stihle M, Müller K, Diederich F. Olsen JA, et al. Among authors: banner dw. Angew Chem Int Ed Engl. 2003 Jun 6;42(22):2507-11. doi: 10.1002/anie.200351268. Angew Chem Int Ed Engl. 2003. PMID: 12800172 No abstract available.

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