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Page 1
Optimization of triazine nitriles as rhodesain inhibitors: structure-activity relationships, bioisosteric imidazopyridine nitriles, and X-ray crystal structure analysis with human cathepsin L.
Ehmke V, Winkler E, Banner DW, Haap W, Schweizer WB, Rottmann M, Kaiser M, Freymond C, Schirmeister T, Diederich F. Ehmke V, et al. Among authors: freymond c. ChemMedChem. 2013 Jun;8(6):967-75. doi: 10.1002/cmdc.201300112. Epub 2013 May 9. ChemMedChem. 2013. PMID: 23658062
Inhibitors of plasmodial serine hydroxymethyltransferase (SHMT): cocrystal structures of pyrazolopyrans with potent blood- and liver-stage activities.
Witschel MC, Rottmann M, Schwab A, Leartsakulpanich U, Chitnumsub P, Seet M, Tonazzi S, Schwertz G, Stelzer F, Mietzner T, McNamara C, Thater F, Freymond C, Jaruwat A, Pinthong C, Riangrungroj P, Oufir M, Hamburger M, Mäser P, Sanz-Alonso LM, Charman S, Wittlin S, Yuthavong Y, Chaiyen P, Diederich F. Witschel MC, et al. Among authors: freymond c. J Med Chem. 2015 Apr 9;58(7):3117-30. doi: 10.1021/jm501987h. Epub 2015 Mar 18. J Med Chem. 2015. PMID: 25785478
Deorphaning pyrrolopyrazines as potent multi-target antimalarial agents.
Reker D, Seet M, Pillong M, Koch CP, Schneider P, Witschel MC, Rottmann M, Freymond C, Brun R, Schweizer B, Illarionov B, Bacher A, Fischer M, Diederich F, Schneider G. Reker D, et al. Among authors: freymond c. Angew Chem Int Ed Engl. 2014 Jul 1;53(27):7079-84. doi: 10.1002/anie.201311162. Epub 2014 Jun 4. Angew Chem Int Ed Engl. 2014. PMID: 24895172
Characterization of a serine hydrolase targeted by acyl-protein thioesterase inhibitors in Toxoplasma gondii.
Kemp LE, Rusch M, Adibekian A, Bullen HE, Graindorge A, Freymond C, Rottmann M, Braun-Breton C, Baumeister S, Porfetye AT, Vetter IR, Hedberg C, Soldati-Favre D. Kemp LE, et al. Among authors: freymond c. J Biol Chem. 2013 Sep 20;288(38):27002-27018. doi: 10.1074/jbc.M113.460709. Epub 2013 Aug 2. J Biol Chem. 2013. PMID: 23913689 Free PMC article.
Heterochromatin protein 1 secures survival and transmission of malaria parasites.
Brancucci NMB, Bertschi NL, Zhu L, Niederwieser I, Chin WH, Wampfler R, Freymond C, Rottmann M, Felger I, Bozdech Z, Voss TS. Brancucci NMB, et al. Among authors: freymond c. Cell Host Microbe. 2014 Aug 13;16(2):165-176. doi: 10.1016/j.chom.2014.07.004. Cell Host Microbe. 2014. PMID: 25121746 Free article.
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