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A multi-site comparison of in vivo safety pharmacology studies conducted to support ICH S7A & B regulatory submissions.
Ewart L, Milne A, Adkins D, Benjamin A, Bialecki R, Chen Y, Ericsson AC, Gardner S, Grant C, Lengel D, Lindgren S, Lowing S, Marks L, Moors J, Oldman K, Pietras M, Prior H, Punton J, Redfern WS, Salmond R, Skinner M, Some M, Stanton A, Swedberg M, Finch J, Valentin JP. Ewart L, et al. Among authors: lengel d. J Pharmacol Toxicol Methods. 2013 Jul-Aug;68(1):30-43. doi: 10.1016/j.vascn.2013.04.008. Epub 2013 May 9. J Pharmacol Toxicol Methods. 2013. PMID: 23665080
Assessment of cisplatin-induced kidney injury using an integrated rodent platform.
Chen Y, Brott D, Luo W, Gangl E, Kamendi H, Barthlow H, Lengel D, Fikes J, Kinter L, Valentin JP, Bialecki R. Chen Y, et al. Among authors: lengel d. Toxicol Appl Pharmacol. 2013 May 1;268(3):352-61. doi: 10.1016/j.taap.2013.01.032. Epub 2013 Feb 13. Toxicol Appl Pharmacol. 2013. PMID: 23415679
The contribution of VEGF signalling to fostamatinib-induced blood pressure elevation.
Skinner M, Philp K, Lengel D, Coverley L, Lamm Bergström E, Glaves P, Musgrove H, Prior H, Braddock M, Huby R, Curwen JO, Duffy P, Harmer AR. Skinner M, et al. Among authors: lengel d. Br J Pharmacol. 2014 May;171(9):2308-20. doi: 10.1111/bph.12559. Br J Pharmacol. 2014. PMID: 24329544 Free PMC article.
Differential blockade by tachykinin NK1 and NK2 receptor antagonists of bronchoconstriction induced by direct-acting agonists and the indirect-acting mimetics capsaicin, serotonin and 2-methyl-serotonin in the anesthetized guinea pig.
Buckner CK, Liberati N, Dea D, Lengel D, Stinson-Fisher C, Campbell J, Miller S, Shenvi A, Krell RD. Buckner CK, et al. Among authors: lengel d. J Pharmacol Exp Ther. 1993 Dec;267(3):1168-75. J Pharmacol Exp Ther. 1993. PMID: 8263778
Tachykinin-induced dyspnea in conscious guinea pigs.
Kusner EJ, Buckner CK, DeHaas CJ, Lengel DJ, Marks RL, Krell RD. Kusner EJ, et al. Among authors: lengel dj. Eur J Pharmacol. 1992 Jan 21;210(3):299-306. doi: 10.1016/0014-2999(92)90419-5. Eur J Pharmacol. 1992. PMID: 1377129
17 results