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Page 1
Discovery of a potent boronic acid derived inhibitor of the HCV RNA-dependent RNA polymerase.
Maynard A, Crosby RM, Ellis B, Hamatake R, Hong Z, Johns BA, Kahler KM, Koble C, Leivers A, Leivers MR, Mathis A, Peat AJ, Pouliot JJ, Roberts CD, Samano V, Schmidt RM, Smith GK, Spaltenstein A, Stewart EL, Thommes P, Turner EM, Voitenleitner C, Walker JT, Waitt G, Weatherhead J, Weaver K, Williams S, Wright L, Xiong ZZ, Haigh D, Shotwell JB. Maynard A, et al. Among authors: hamatake r. J Med Chem. 2014 Mar 13;57(5):1902-13. doi: 10.1021/jm400317w. Epub 2013 May 29. J Med Chem. 2014. PMID: 23672667
In vitro characterization of GSK2485852, a novel hepatitis C virus polymerase inhibitor.
Voitenleitner C, Crosby R, Walker J, Remlinger K, Vamathevan J, Wang A, You S, Johnson J 3rd, Woldu E, Van Horn S, Horton J, Creech K, Shotwell JB, Hong Z, Hamatake R. Voitenleitner C, et al. Among authors: hamatake r. Antimicrob Agents Chemother. 2013 Nov;57(11):5216-24. doi: 10.1128/AAC.00874-13. Epub 2013 Aug 12. Antimicrob Agents Chemother. 2013. PMID: 23939896 Free PMC article.
Discovery of novel urea-based hepatitis C protease inhibitors with high potency against protease-inhibitor-resistant mutants.
Kazmierski WM, Hamatake R, Duan M, Wright LL, Smith GK, Jarvest RL, Ji JJ, Cooper JP, Tallant MD, Crosby RM, Creech K, Wang A, Li X, Zhang S, Zhang YK, Liu Y, Ding CZ, Zhou Y, Plattner JJ, Baker SJ, Bu W, Liu L. Kazmierski WM, et al. Among authors: hamatake r. J Med Chem. 2012 Apr 12;55(7):3021-6. doi: 10.1021/jm201278q. Epub 2012 Apr 3. J Med Chem. 2012. PMID: 22471376
Hepatitis C replication inhibitors that target the viral NS4B protein.
Miller JF, Chong PY, Shotwell JB, Catalano JG, Tai VW, Fang J, Banka AL, Roberts CD, Youngman M, Zhang H, Xiong Z, Mathis A, Pouliot JJ, Hamatake RK, Price DJ, Seal JW 3rd, Stroup LL, Creech KL, Carballo LH, Todd D, Spaltenstein A, Furst S, Hong Z, Peat AJ. Miller JF, et al. J Med Chem. 2014 Mar 13;57(5):2107-20. doi: 10.1021/jm400125h. Epub 2013 Apr 19. J Med Chem. 2014. PMID: 23544424
Synthesis and antiviral activity of novel HCV NS3 protease inhibitors with P4 capping groups.
Li X, Liu Y, Zhang YK, Plattner JJ, Baker SJ, Bu W, Liu L, Zhou Y, Ding CZ, Zhang S, Kazmierski WM, Hamatake R, Duan M, Wright LL, Smith GK, Jarvest RL, Ji JJ, Cooper JP, Tallant MD, Crosby RM, Creech K, Wang A. Li X, et al. Among authors: hamatake r. Bioorg Med Chem Lett. 2012 Dec 15;22(24):7351-6. doi: 10.1016/j.bmcl.2012.10.075. Epub 2012 Oct 22. Bioorg Med Chem Lett. 2012. PMID: 23142614
Preclinical characterization of GSK2336805, a novel inhibitor of hepatitis C virus replication that selects for resistance in NS5A.
Walker J, Crosby R, Wang A, Woldu E, Vamathevan J, Voitenleitner C, You S, Remlinger K, Duan M, Kazmierski W, Hamatake R. Walker J, et al. Among authors: hamatake r. Antimicrob Agents Chemother. 2014;58(1):38-47. doi: 10.1128/AAC.01363-13. Epub 2013 Oct 14. Antimicrob Agents Chemother. 2014. PMID: 24126581 Free PMC article.
67 results