Sproul D - Search Results

1

Expression of a large LINE-1-driven antisense RNA is linked to epigenetic silencing of the metastasis suppressor gene TFPI-2 in cancer.

Cruickshanks HA, Vafadar-Isfahani N, Dunican DS, Lee A, Sproul D, Lund JN, Meehan RR, Tufarelli C. Cruickshanks HA, et al. Among authors: sproul d. Nucleic Acids Res. 2013 Aug;41(14):6857-69. doi: 10.1093/nar/gkt438. Epub 2013 May 23. Nucleic Acids Res. 2013. PMID: 23703216 Free PMC article.

2

Transcriptionally repressed genes become aberrantly methylated and distinguish tumors of different lineages in breast cancer.

Sproul D, Nestor C, Culley J, Dickson JH, Dixon JM, Harrison DJ, Meehan RR, Sims AH, Ramsahoye BH. Sproul D, et al. Proc Natl Acad Sci U S A. 2011 Mar 15;108(11):4364-9. doi: 10.1073/pnas.1013224108. Epub 2011 Feb 28. Proc Natl Acad Sci U S A. 2011. PMID: 21368160 Free PMC article.

3

Tissue type is a major modifier of the 5-hydroxymethylcytosine content of human genes.

Nestor CE, Ottaviano R, Reddington J, Sproul D, Reinhardt D, Dunican D, Katz E, Dixon JM, Harrison DJ, Meehan RR. Nestor CE, et al. Among authors: sproul d. Genome Res. 2012 Mar;22(3):467-77. doi: 10.1101/gr.126417.111. Epub 2011 Nov 21. Genome Res. 2012. PMID: 22106369 Free PMC article.

4

Targeting of Rac GTPases blocks the spread of intact human breast cancer.

Katz E, Sims AH, Sproul D, Caldwell H, Dixon MJ, Meehan RR, Harrison DJ. Katz E, et al. Among authors: sproul d. Oncotarget. 2012 Jun;3(6):608-19. doi: 10.18632/oncotarget.520. Oncotarget. 2012. PMID: 22689141 Free PMC article.

5

Tissue of origin determines cancer-associated CpG island promoter hypermethylation patterns.

Sproul D, Kitchen RR, Nestor CE, Dixon JM, Sims AH, Harrison DJ, Ramsahoye BH, Meehan RR. Sproul D, et al. Genome Biol. 2012 Oct 3;13(10):R84. doi: 10.1186/gb-2012-13-10-r84. Genome Biol. 2012. PMID: 23034185 Free PMC article.

6

Genomic insights into cancer-associated aberrant CpG island hypermethylation.

Sproul D, Meehan RR. Sproul D, et al. Brief Funct Genomics. 2013 May;12(3):174-90. doi: 10.1093/bfgp/els063. Epub 2013 Jan 21. Brief Funct Genomics. 2013. PMID: 23341493 Free PMC article. Review.

7

DNA methylation reprogramming in cancer: does it act by re-configuring the binding landscape of Polycomb repressive complexes?

Reddington JP, Sproul D, Meehan RR. Reddington JP, et al. Among authors: sproul d. Bioessays. 2014 Feb;36(2):134-40. doi: 10.1002/bies.201300130. Epub 2013 Nov 26. Bioessays. 2014. PMID: 24277643 Free PMC article.

8

Diverse interventions that extend mouse lifespan suppress shared age-associated epigenetic changes at critical gene regulatory regions.

Cole JJ, Robertson NA, Rather MI, Thomson JP, McBryan T, Sproul D, Wang T, Brock C, Clark W, Ideker T, Meehan RR, Miller RA, Brown-Borg HM, Adams PD. Cole JJ, et al. Among authors: sproul d. Genome Biol. 2017 Mar 28;18(1):58. doi: 10.1186/s13059-017-1185-3. Genome Biol. 2017. PMID: 28351383 Free PMC article.

9

Activation of transcription factor circuity in 2i-induced ground state pluripotency is independent of repressive global epigenetic landscapes.

Shukla R, Mjoseng HK, Thomson JP, Kling S, Sproul D, Dunican DS, Ramsahoye B, Wongtawan T, Treindl F, Templin MF, Adams IR, Pennings S, Meehan RR. Shukla R, et al. Among authors: sproul d. Nucleic Acids Res. 2020 Aug 20;48(14):7748-7766. doi: 10.1093/nar/gkaa529. Nucleic Acids Res. 2020. PMID: 32585002 Free PMC article.

10

Lactate, a product of glycolytic metabolism, inhibits histone deacetylase activity and promotes changes in gene expression.

Latham T, Mackay L, Sproul D, Karim M, Culley J, Harrison DJ, Hayward L, Langridge-Smith P, Gilbert N, Ramsahoye BH. Latham T, et al. Among authors: sproul d. Nucleic Acids Res. 2012 Jun;40(11):4794-803. doi: 10.1093/nar/gks066. Epub 2012 Feb 9. Nucleic Acids Res. 2012. PMID: 22323521 Free PMC article.

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