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Atg16l1 is required for autophagy in intestinal epithelial cells and protection of mice from Salmonella infection.
Conway KL, Kuballa P, Song JH, Patel KK, Castoreno AB, Yilmaz OH, Jijon HB, Zhang M, Aldrich LN, Villablanca EJ, Peloquin JM, Goel G, Lee IA, Mizoguchi E, Shi HN, Bhan AK, Shaw SY, Schreiber SL, Virgin HW, Shamji AF, Stappenbeck TS, Reinecker HC, Xavier RJ. Conway KL, et al. Among authors: villablanca ej. Gastroenterology. 2013 Dec;145(6):1347-57. doi: 10.1053/j.gastro.2013.08.035. Epub 2013 Aug 21. Gastroenterology. 2013. PMID: 23973919 Free PMC article.
Atg16L1 T300A variant decreases selective autophagy resulting in altered cytokine signaling and decreased antibacterial defense.
Lassen KG, Kuballa P, Conway KL, Patel KK, Becker CE, Peloquin JM, Villablanca EJ, Norman JM, Liu TC, Heath RJ, Becker ML, Fagbami L, Horn H, Mercer J, Yilmaz OH, Jaffe JD, Shamji AF, Bhan AK, Carr SA, Daly MJ, Virgin HW, Schreiber SL, Stappenbeck TS, Xavier RJ. Lassen KG, et al. Among authors: villablanca ej. Proc Natl Acad Sci U S A. 2014 May 27;111(21):7741-6. doi: 10.1073/pnas.1407001111. Epub 2014 May 12. Proc Natl Acad Sci U S A. 2014. PMID: 24821797 Free PMC article.
Mechanisms of Pediatric Inflammatory Bowel Disease.
Peloquin JM, Goel G, Villablanca EJ, Xavier RJ. Peloquin JM, et al. Among authors: villablanca ej. Annu Rev Immunol. 2016 May 20;34:31-64. doi: 10.1146/annurev-immunol-032414-112151. Annu Rev Immunol. 2016. PMID: 27168239 Review.
Intestinal epithelial cell-specific RARα depletion results in aberrant epithelial cell homeostasis and underdeveloped immune system.
Jijon HB, Suarez-Lopez L, Diaz OE, Das S, De Calisto J, Parada-kusz M, Yaffe MB, Pittet MJ, Mora JR, Belkaid Y, Xavier RJ, Villablanca EJ. Jijon HB, et al. Among authors: villablanca ej. Mucosal Immunol. 2018 May;11(3):703-715. doi: 10.1038/mi.2017.91. Epub 2017 Nov 15. Mucosal Immunol. 2018. PMID: 29139475 Free PMC article.
Integrated Genomics of Crohn's Disease Risk Variant Identifies a Role for CLEC12A in Antibacterial Autophagy.
Begun J, Lassen KG, Jijon HB, Baxt LA, Goel G, Heath RJ, Ng A, Tam JM, Kuo SY, Villablanca EJ, Fagbami L, Oosting M, Kumar V, Schenone M, Carr SA, Joosten LA, Vyas JM, Daly MJ, Netea MG, Brown GD, Wijmenga C, Xavier RJ. Begun J, et al. Among authors: villablanca ej. Cell Rep. 2015 Jun 30;11(12):1905-18. doi: 10.1016/j.celrep.2015.05.045. Epub 2015 Jun 18. Cell Rep. 2015. PMID: 26095365 Free PMC article.
MyD88-dependent TLR1/2 signals educate dendritic cells with gut-specific imprinting properties.
Wang S, Villablanca EJ, De Calisto J, Gomes DC, Nguyen DD, Mizoguchi E, Kagan JC, Reinecker HC, Hacohen N, Nagler C, Xavier RJ, Rossi-Bergmann B, Chen YB, Blomhoff R, Snapper SB, Mora JR. Wang S, et al. Among authors: villablanca ej. J Immunol. 2011 Jul 1;187(1):141-50. doi: 10.4049/jimmunol.1003740. Epub 2011 Jun 6. J Immunol. 2011. PMID: 21646294 Free PMC article.
Genetic Coding Variant in GPR65 Alters Lysosomal pH and Links Lysosomal Dysfunction with Colitis Risk.
Lassen KG, McKenzie CI, Mari M, Murano T, Begun J, Baxt LA, Goel G, Villablanca EJ, Kuo SY, Huang H, Macia L, Bhan AK, Batten M, Daly MJ, Reggiori F, Mackay CR, Xavier RJ. Lassen KG, et al. Among authors: villablanca ej. Immunity. 2016 Jun 21;44(6):1392-405. doi: 10.1016/j.immuni.2016.05.007. Epub 2016 Jun 7. Immunity. 2016. PMID: 27287411 Free PMC article.
85 results