Eichelbaum M - Search Results

1

Patients with type II autoimmune hepatitis express functionally intact cytochrome P-450 db1 that is inhibited by LKM-1 autoantibodies in vitro but not in vivo.

Manns M, Zanger U, Gerken G, Sullivan KF, Meyer zum Büschenfelde KH, Meyer UA, Eichelbaum M. Manns M, et al. Among authors: eichelbaum m. Hepatology. 1990 Jul;12(1):127-32. doi: 10.1002/hep.1840120120. Hepatology. 1990. PMID: 2373473

2

In vitro characterization of the human cytochrome P-450 involved in polymorphic oxidation of propafenone.

Kroemer HK, Mikus G, Kronbach T, Meyer UA, Eichelbaum M. Kroemer HK, et al. Among authors: eichelbaum m. Clin Pharmacol Ther. 1989 Jan;45(1):28-33. doi: 10.1038/clpt.1989.5. Clin Pharmacol Ther. 1989. PMID: 2910635

3

Enzymatic basis of the debrisoquine/sparteine-type genetic polymorphism of drug oxidation. Characterization of bufuralol 1'-hydroxylation in liver microsomes of in vivo phenotyped carriers of the genetic deficiency.

Dayer P, Kronbach T, Eichelbaum M, Meyer UA. Dayer P, et al. Among authors: eichelbaum m. Biochem Pharmacol. 1987 Dec 1;36(23):4145-52. doi: 10.1016/0006-2952(87)90573-9. Biochem Pharmacol. 1987. PMID: 3689440

4

Evidence for altered catalytic properties of the cytochrome P-450 involved in sparteine oxidation in poor metabolizers.

Osikowska-Evers B, Dayer P, Meyer UA, Robertz GM, Eichelbaum M. Osikowska-Evers B, et al. Among authors: eichelbaum m. Clin Pharmacol Ther. 1987 Mar;41(3):320-5. doi: 10.1038/clpt.1987.34. Clin Pharmacol Ther. 1987. PMID: 3816020

5

Characterization of a common genetic defect of cytochrome P-450 function (debrisoquine-sparteine type polymorphism)--increased Michaelis is Constant (Km) and loss of stereoselectivity of bufuralol 1'-hydroxylation in poor metabolizers.

Dayer P, Gasser R, Gut J, Kronbach T, Robertz GM, Eichelbaum M, Meyer UA. Dayer P, et al. Among authors: eichelbaum m. Biochem Biophys Res Commun. 1984 Nov 30;125(1):374-80. doi: 10.1016/s0006-291x(84)80378-2. Biochem Biophys Res Commun. 1984. PMID: 6508804

6

Deletion of the entire cytochrome P450 CYP2D6 gene as a cause of impaired drug metabolism in poor metabolizers of the debrisoquine/sparteine polymorphism.

Gaedigk A, Blum M, Gaedigk R, Eichelbaum M, Meyer UA. Gaedigk A, et al. Among authors: eichelbaum m. Am J Hum Genet. 1991 May;48(5):943-50. Am J Hum Genet. 1991. PMID: 1673290 Free PMC article.

7

Debrisoquine/sparteine hydroxylation genotype and phenotype: analysis of common mutations and alleles of CYP2D6 in a European population.

Broly F, Gaedigk A, Heim M, Eichelbaum M, Morike K, Meyer UA. Broly F, et al. Among authors: eichelbaum m. DNA Cell Biol. 1991 Oct;10(8):545-58. doi: 10.1089/dna.1991.10.545. DNA Cell Biol. 1991. PMID: 1681816

8

Acetylation pharmacogenetics. The slow acetylator phenotype is caused by decreased or absent arylamine N-acetyltransferase in human liver.

Grant DM, Mörike K, Eichelbaum M, Meyer UA. Grant DM, et al. Among authors: eichelbaum m. J Clin Invest. 1990 Mar;85(3):968-72. doi: 10.1172/JCI114527. J Clin Invest. 1990. PMID: 2312737 Free PMC article.

9

Functional properties of CYP2D6 1 (wild-type) and CYP2D6 7 (His324Pro) expressed by recombinant baculovirus in insect cells.

Evert B, Eichelbaum M, Haubruck H, Zanger UM. Evert B, et al. Among authors: eichelbaum m. Naunyn Schmiedebergs Arch Pharmacol. 1997 Mar;355(3):309-18. doi: 10.1007/pl00004948. Naunyn Schmiedebergs Arch Pharmacol. 1997. PMID: 9089660

10

Elucidation of the genetic basis of the common 'intermediate metabolizer' phenotype for drug oxidation by CYP2D6.

Raimundo S, Fischer J, Eichelbaum M, Griese EU, Schwab M, Zanger UM. Raimundo S, et al. Among authors: eichelbaum m. Pharmacogenetics. 2000 Oct;10(7):577-81. doi: 10.1097/00008571-200010000-00001. Pharmacogenetics. 2000. PMID: 11037799

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