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Page 1
Design, synthesis, and biological evaluation of (E)-N-aryl-2-arylethenesulfonamide analogues as potent and orally bioavailable microtubule-targeted anticancer agents.
Reddy MV, Mallireddigari MR, Pallela VR, Cosenza SC, Billa VK, Akula B, Subbaiah DR, Bharathi EV, Padgaonkar A, Lv H, Gallo JM, Reddy EP. Reddy MV, et al. Among authors: padgaonkar a. J Med Chem. 2013 Jul 11;56(13):5562-86. doi: 10.1021/jm400575x. Epub 2013 Jun 25. J Med Chem. 2013. PMID: 23750455 Free PMC article.
Discovery of 8-cyclopentyl-2-[4-(4-methyl-piperazin-1-yl)-phenylamino]-7-oxo-7,8-dihydro-pyrido[2,3-d]pyrimidine-6-carbonitrile (7x) as a potent inhibitor of cyclin-dependent kinase 4 (CDK4) and AMPK-related kinase 5 (ARK5).
Reddy MV, Akula B, Cosenza SC, Athuluridivakar S, Mallireddigari MR, Pallela VR, Billa VK, Subbaiah DR, Bharathi EV, Vasquez-Del Carpio R, Padgaonkar A, Baker SJ, Reddy EP. Reddy MV, et al. Among authors: padgaonkar a. J Med Chem. 2014 Feb 13;57(3):578-99. doi: 10.1021/jm401073p. Epub 2014 Jan 24. J Med Chem. 2014. PMID: 24417566 Free PMC article.
Simultaneous CK2/TNIK/DYRK1 inhibition by 108600 suppresses triple negative breast cancer stem cells and chemotherapy-resistant disease.
Sato K, Padgaonkar AA, Baker SJ, Cosenza SC, Rechkoblit O, Subbaiah DRCV, Domingo-Domenech J, Bartkowski A, Port ER, Aggarwal AK, Ramana Reddy MV, Irie HY, Reddy EP. Sato K, et al. Among authors: padgaonkar aa. Nat Commun. 2021 Aug 3;12(1):4671. doi: 10.1038/s41467-021-24878-z. Nat Commun. 2021. PMID: 34344863 Free PMC article.
Targeting protein kinase CK2 and CDK4/6 pathways with a multi-kinase inhibitor ON108110 suppresses pro-survival signaling and growth in mantle cell lymphoma and T-acute lymphoblastic leukemia.
Padgaonkar A, Rechkoblit O, Vasquez-Del Carpio R, Pallela V, Venkata Subbaiah D, Cosenza SC, Baker SJ, Ramana Reddy MV, Aggarwal A, Reddy EP. Padgaonkar A, et al. Oncotarget. 2018 Dec 28;9(102):37753-37765. doi: 10.18632/oncotarget.26514. eCollection 2018 Dec 28. Oncotarget. 2018. PMID: 30701029 Free PMC article.
15 results