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NPHP4, a cilia-associated protein, negatively regulates the Hippo pathway.
Habbig S, Bartram MP, Müller RU, Schwarz R, Andriopoulos N, Chen S, Sägmüller JG, Hoehne M, Burst V, Liebau MC, Reinhardt HC, Benzing T, Schermer B. Habbig S, et al. Among authors: reinhardt hc. J Cell Biol. 2011 May 16;193(4):633-42. doi: 10.1083/jcb.201009069. Epub 2011 May 9. J Cell Biol. 2011. PMID: 21555462 Free PMC article.
AATF/Che-1 acts as a phosphorylation-dependent molecular modulator to repress p53-driven apoptosis.
Höpker K, Hagmann H, Khurshid S, Chen S, Hasskamp P, Seeger-Nukpezah T, Schilberg K, Heukamp L, Lamkemeyer T, Sos ML, Thomas RK, Lowery D, Roels F, Fischer M, Liebau MC, Resch U, Kisner T, Röther F, Bartram MP, Müller RU, Fabretti F, Kurschat P, Schumacher B, Gaestel M, Medema RH, Yaffe MB, Schermer B, Reinhardt HC, Benzing T. Höpker K, et al. Among authors: reinhardt hc. EMBO J. 2012 Oct 17;31(20):3961-75. doi: 10.1038/emboj.2012.236. Epub 2012 Aug 21. EMBO J. 2012. PMID: 22909821 Free PMC article.
Putting the brakes on p53-driven apoptosis.
Höpker K, Hagmann H, Khurshid S, Chen S, Schermer B, Benzing T, Reinhardt HC. Höpker K, et al. Among authors: reinhardt hc. Cell Cycle. 2012 Nov 15;11(22):4122-8. doi: 10.4161/cc.21997. Epub 2012 Sep 14. Cell Cycle. 2012. PMID: 22983126 Free PMC article.
Cell-autonomous and non-cell-autonomous mechanisms of transformation by amplified FGFR1 in lung cancer.
Malchers F, Dietlein F, Schöttle J, Lu X, Nogova L, Albus K, Fernandez-Cuesta L, Heuckmann JM, Gautschi O, Diebold J, Plenker D, Gardizi M, Scheffler M, Bos M, Seidel D, Leenders F, Richters A, Peifer M, Florin A, Mainkar PS, Karre N, Chandrasekhar S, George J, Silling S, Rauh D, Zander T, Ullrich RT, Reinhardt HC, Ringeisen F, Büttner R, Heukamp LC, Wolf J, Thomas RK. Malchers F, et al. Among authors: reinhardt hc. Cancer Discov. 2014 Feb;4(2):246-57. doi: 10.1158/2159-8290.CD-13-0323. Epub 2013 Dec 3. Cancer Discov. 2014. PMID: 24302556
Hypoxia-induced p38 MAPK activation reduces Mcl-1 expression and facilitates sensitivity towards BH3 mimetics in chronic lymphocytic leukemia.
Huelsemann MF, Patz M, Beckmann L, Brinkmann K, Otto T, Fandrey J, Becker HJ, Theurich S, von Bergwelt-Baildon M, Pallasch CP, Zahedi RP, Kashkar H, Reinhardt HC, Hallek M, Wendtner CM, Frenzel LP. Huelsemann MF, et al. Among authors: reinhardt hc. Leukemia. 2015 Apr;29(4):981-4. doi: 10.1038/leu.2014.320. Epub 2014 Nov 7. Leukemia. 2015. PMID: 25376373 No abstract available.
Label-Free Protein-RNA Interactome Analysis Identifies Khsrp Signaling Downstream of the p38/Mk2 Kinase Complex as a Critical Modulator of Cell Cycle Progression.
Boucas J, Fritz C, Schmitt A, Riabinska A, Thelen L, Peifer M, Leeser U, Nuernberg P, Altmueller J, Gaestel M, Dieterich C, Reinhardt HC. Boucas J, et al. Among authors: reinhardt hc. PLoS One. 2015 May 20;10(5):e0125745. doi: 10.1371/journal.pone.0125745. eCollection 2015. PLoS One. 2015. PMID: 25993413 Free PMC article.
A Synergistic Interaction between Chk1- and MK2 Inhibitors in KRAS-Mutant Cancer.
Dietlein F, Kalb B, Jokic M, Noll EM, Strong A, Tharun L, Ozretić L, Künstlinger H, Kambartel K, Randerath WJ, Jüngst C, Schmitt A, Torgovnick A, Richters A, Rauh D, Siedek F, Persigehl T, Mauch C, Bartkova J, Bradley A, Sprick MR, Trumpp A, Rad R, Saur D, Bartek J, Wolf J, Büttner R, Thomas RK, Reinhardt HC. Dietlein F, et al. Among authors: reinhardt hc. Cell. 2015 Jul 2;162(1):146-59. doi: 10.1016/j.cell.2015.05.053. Cell. 2015. PMID: 26140595 Free article.
187 results