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Preclinical Development of Crocus sativus-Based Botanical Lead IIIM-141 for Alzheimer's Disease: Chemical Standardization, Efficacy, Formulation Development, Pharmacokinetics, and Safety Pharmacology.
Bharate SS, Kumar V, Singh G, Singh A, Gupta M, Singh D, Kumar A, Vishwakarma RA, Bharate SB. Bharate SS, et al. Among authors: kumar v, kumar a. ACS Omega. 2018 Aug 20;3(8):9572-9585. doi: 10.1021/acsomega.8b00841. eCollection 2018 Aug 31. ACS Omega. 2018. PMID: 31459089 Free PMC article.
Crocetin promotes clearance of amyloid-β by inducing autophagy via the STK11/LKB1-mediated AMPK pathway.
Wani A, Al Rihani SB, Sharma A, Weadick B, Govindarajan R, Khan SU, Sharma PR, Dogra A, Nandi U, Reddy CN, Bharate SS, Singh G, Bharate SB, Vishwakarma RA, Kaddoumi A, Kumar A. Wani A, et al. Among authors: kumar a. Autophagy. 2021 Nov;17(11):3813-3832. doi: 10.1080/15548627.2021.1872187. Epub 2021 Jan 19. Autophagy. 2021. PMID: 33404280 Free PMC article.
Safranal inhibits NLRP3 inflammasome activation by preventing ASC oligomerization.
Gupta M, Wani A, Ahsan AU, Ali M, Chibber P, Singh S, Digra SK, Datt M, Bharate SB, Vishwakarma RA, Singh G, Kumar A. Gupta M, et al. Among authors: kumar a. Toxicol Appl Pharmacol. 2021 Jul 15;423:115582. doi: 10.1016/j.taap.2021.115582. Epub 2021 May 18. Toxicol Appl Pharmacol. 2021. PMID: 34019860
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