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Amphetamine actions at the serotonin transporter rely on the availability of phosphatidylinositol-4,5-bisphosphate.
Buchmayer F, Schicker K, Steinkellner T, Geier P, Stübiger G, Hamilton PJ, Jurik A, Stockner T, Yang JW, Montgomery T, Holy M, Hofmaier T, Kudlacek O, Matthies HJ, Ecker GF, Bochkov V, Galli A, Boehm S, Sitte HH. Buchmayer F, et al. Among authors: holy m. Proc Natl Acad Sci U S A. 2013 Jul 9;110(28):11642-7. doi: 10.1073/pnas.1220552110. Epub 2013 Jun 24. Proc Natl Acad Sci U S A. 2013. PMID: 23798435 Free PMC article.
N,N-dimethyl-thioamphetamine and methyl-thioamphetamine, two non-neurotoxic substrates of 5-HT transporters, have scant in vitro efficacy for the induction of transporter-mediated 5-HT release and currents.
Gobbi M, Funicello M, Gerstbrein K, Holy M, Moya PR, Sotomayor R, Forray MI, Gysling K, Paluzzi S, Bonanno G, Reyes-Parada M, Sitte HH, Mennini T. Gobbi M, et al. Among authors: holy m. J Neurochem. 2008 Jun;105(5):1770-80. doi: 10.1111/j.1471-4159.2008.05272.x. Epub 2008 Feb 4. J Neurochem. 2008. PMID: 18248615 Free PMC article.
The N terminus of monoamine transporters is a lever required for the action of amphetamines.
Sucic S, Dallinger S, Zdrazil B, Weissensteiner R, Jørgensen TN, Holy M, Kudlacek O, Seidel S, Cha JH, Gether U, Newman AH, Ecker GF, Freissmuth M, Sitte HH. Sucic S, et al. Among authors: holy m. J Biol Chem. 2010 Apr 2;285(14):10924-38. doi: 10.1074/jbc.M109.083154. Epub 2010 Jan 29. J Biol Chem. 2010. PMID: 20118234 Free PMC article.
127 results