Lindquist S - Search Results

1

Chaperones as thermodynamic sensors of drug-target interactions reveal kinase inhibitor specificities in living cells.

Taipale M, Krykbaeva I, Whitesell L, Santagata S, Zhang J, Liu Q, Gray NS, Lindquist S. Taipale M, et al. Among authors: lindquist s. Nat Biotechnol. 2013 Jul;31(7):630-7. doi: 10.1038/nbt.2620. Epub 2013 Jun 30. Nat Biotechnol. 2013. PMID: 23811600 Free PMC article.

2

HSP90 at the hub of protein homeostasis: emerging mechanistic insights.

Taipale M, Jarosz DF, Lindquist S. Taipale M, et al. Among authors: lindquist s. Nat Rev Mol Cell Biol. 2010 Jul;11(7):515-28. doi: 10.1038/nrm2918. Epub 2010 Jun 9. Nat Rev Mol Cell Biol. 2010. PMID: 20531426 Review.

3

HSP90 and the chaperoning of cancer.

Whitesell L, Lindquist SL. Whitesell L, et al. Nat Rev Cancer. 2005 Oct;5(10):761-72. doi: 10.1038/nrc1716. Nat Rev Cancer. 2005. PMID: 16175177 Review.

4

HSF1 phase transition mediates stress adaptation and cell fate decisions.

Gaglia G, Rashid R, Yapp C, Joshi GN, Li CG, Lindquist SL, Sarosiek KA, Whitesell L, Sorger PK, Santagata S. Gaglia G, et al. Among authors: lindquist sl. Nat Cell Biol. 2020 Feb;22(2):151-158. doi: 10.1038/s41556-019-0458-3. Epub 2020 Feb 3. Nat Cell Biol. 2020. PMID: 32015439 Free PMC article.

5

Inhibiting the transcription factor HSF1 as an anticancer strategy.

Whitesell L, Lindquist S. Whitesell L, et al. Among authors: lindquist s. Expert Opin Ther Targets. 2009 Apr;13(4):469-78. doi: 10.1517/14728220902832697. Expert Opin Ther Targets. 2009. PMID: 19335068 Review.

6

Quantitative analysis of HSP90-client interactions reveals principles of substrate recognition.

Taipale M, Krykbaeva I, Koeva M, Kayatekin C, Westover KD, Karras GI, Lindquist S. Taipale M, et al. Among authors: lindquist s. Cell. 2012 Aug 31;150(5):987-1001. doi: 10.1016/j.cell.2012.06.047. Cell. 2012. PMID: 22939624 Free PMC article.

7

The mammalian-membrane two-hybrid assay (MaMTH) for probing membrane-protein interactions in human cells.

Petschnigg J, Groisman B, Kotlyar M, Taipale M, Zheng Y, Kurat CF, Sayad A, Sierra JR, Mattiazzi Usaj M, Snider J, Nachman A, Krykbaeva I, Tsao MS, Moffat J, Pawson T, Lindquist S, Jurisica I, Stagljar I. Petschnigg J, et al. Among authors: lindquist s. Nat Methods. 2014 May;11(5):585-92. doi: 10.1038/nmeth.2895. Epub 2014 Mar 23. Nat Methods. 2014. PMID: 24658140

8

A quantitative chaperone interaction network reveals the architecture of cellular protein homeostasis pathways.

Taipale M, Tucker G, Peng J, Krykbaeva I, Lin ZY, Larsen B, Choi H, Berger B, Gingras AC, Lindquist S. Taipale M, et al. Among authors: lindquist s. Cell. 2014 Jul 17;158(2):434-448. doi: 10.1016/j.cell.2014.05.039. Cell. 2014. PMID: 25036637 Free PMC article.

9

HSP90 empowers evolution of resistance to hormonal therapy in human breast cancer models.

Whitesell L, Santagata S, Mendillo ML, Lin NU, Proia DA, Lindquist S. Whitesell L, et al. Among authors: lindquist s. Proc Natl Acad Sci U S A. 2014 Dec 23;111(51):18297-302. doi: 10.1073/pnas.1421323111. Epub 2014 Dec 8. Proc Natl Acad Sci U S A. 2014. PMID: 25489079 Free PMC article.

10

Structural basis for species-selective targeting of Hsp90 in a pathogenic fungus.

Whitesell L, Robbins N, Huang DS, McLellan CA, Shekhar-Guturja T, LeBlanc EV, Nation CS, Hui R, Hutchinson A, Collins C, Chatterjee S, Trilles R, Xie JL, Krysan DJ, Lindquist S, Porco JA Jr, Tatu U, Brown LE, Pizarro J, Cowen LE. Whitesell L, et al. Among authors: lindquist s. Nat Commun. 2019 Jan 24;10(1):402. doi: 10.1038/s41467-018-08248-w. Nat Commun. 2019. PMID: 30679438 Free PMC article.

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