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Page 1
Chronic glucolipotoxic conditions in pancreatic islets impair insulin secretion due to dysregulated calcium dynamics, glucose responsiveness and mitochondrial activity.
Somesh BP, Verma MK, Sadasivuni MK, Mammen-Oommen A, Biswas S, Shilpa PC, Reddy AK, Yateesh AN, Pallavi PM, Nethra S, Smitha R, Neelima K, Narayanan U, Jagannath MR. Somesh BP, et al. Among authors: sadasivuni mk. BMC Cell Biol. 2013 Jul 1;14:31. doi: 10.1186/1471-2121-14-31. BMC Cell Biol. 2013. PMID: 23815372 Free PMC article.
CNX-011-67, a novel GPR40 agonist, enhances glucose responsiveness, insulin secretion and islet insulin content in n-STZ rats and in islets from type 2 diabetic patients.
Sunil V, Verma MK, Oommen AM, Sadasivuni M, Singh J, Vijayraghav DN, Chandravanshi B, Shetty J, Biswas S, Dandu A, Moolemath Y, Venkataranganna MV, Somesh BP, Jagannath MR. Sunil V, et al. Among authors: sadasivuni m. BMC Pharmacol Toxicol. 2014 Mar 25;15:19. doi: 10.1186/2050-6511-15-19. BMC Pharmacol Toxicol. 2014. PMID: 24666736 Free PMC article.
CNX-013-B2, a unique pan tissue acting rexinoid, modulates several nuclear receptors and controls multiple risk factors of the metabolic syndrome without risk of hypertriglyceridemia, hepatomegaly and body weight gain in animal models.
Sadasivuni MK, Reddy BM, Singh J, Anup MO, Sunil V, Lakshmi MN, Yogeshwari S, Chacko SK, Pooja TL, Dandu A, Harish C, Gopala AS, Pratibha S, Naveenkumar BS, Pallavi PM, Verma MK, Moolemath Y, Somesh BP, Venkataranganna MV, Jagannath MR. Sadasivuni MK, et al. Diabetol Metab Syndr. 2014 Aug 12;6(1):83. doi: 10.1186/1758-5996-6-83. eCollection 2014. Diabetol Metab Syndr. 2014. PMID: 25143786 Free PMC article.
Treatment with CNX-011-67, a novel GPR40 agonist, delays onset and progression of diabetes and improves beta cell preservation and function in male ZDF rats.
Gowda N, Dandu A, Singh J, Biswas S, Raghav V, Lakshmi MN, Shilpa PC, Sunil V, Reddy A, Sadasivuni M, Aparna K, Verma MK, Moolemath Y, Anup MO, Venkataranganna MV, Somesh BP, Jagannath MR. Gowda N, et al. Among authors: sadasivuni m. BMC Pharmacol Toxicol. 2013 May 21;14:28. doi: 10.1186/2050-6511-14-28. BMC Pharmacol Toxicol. 2013. PMID: 23692921 Free PMC article.
A novel 11β-hydroxysteroid dehydrogenase type1 inhibitor CNX-010-49 improves hyperglycemia, lipid profile and reduces body weight in diet induced obese C57B6/J mice with a potential to provide cardio protective benefits.
Anil TM, Dandu A, Harsha K, Singh J, Shree N, Kumar VS, Lakshmi MN, Sunil V, Harish C, Balamurali GV, Naveen Kumar BS, Gopala AS, Pratibha S, Sadasivuni M, Anup MO, Moolemath Y, Venkataranganna MV, Jagannath MR, Somesh BP. Anil TM, et al. BMC Pharmacol Toxicol. 2014 Aug 7;15:43. doi: 10.1186/2050-6511-15-43. BMC Pharmacol Toxicol. 2014. PMID: 25098735 Free PMC article.
Rodent evolution: back to the root.
Churakov G, Sadasivuni MK, Rosenbloom KR, Huchon D, Brosius J, Schmitz J. Churakov G, et al. Among authors: sadasivuni mk. Mol Biol Evol. 2010 Jun;27(6):1315-26. doi: 10.1093/molbev/msq019. Epub 2010 Jan 25. Mol Biol Evol. 2010. PMID: 20100942