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Gleason pattern 5 is the strongest pathologic predictor of recurrence, metastasis, and prostate cancer-specific death in patients receiving salvage radiation therapy following radical prostatectomy.
Jackson W, Hamstra DA, Johnson S, Zhou J, Foster B, Foster C, Li D, Song Y, Palapattu GS, Kunju LP, Mehra R, Feng FY. Jackson W, et al. Among authors: li d. Cancer. 2013 Sep 15;119(18):3287-94. doi: 10.1002/cncr.28215. Epub 2013 Jul 2. Cancer. 2013. PMID: 23821578 Free article.
The interval to biochemical failure is prognostic for metastasis, prostate cancer-specific mortality, and overall mortality after salvage radiation therapy for prostate cancer.
Johnson S, Jackson W, Li D, Song Y, Foster C, Foster B, Zhou J, Vainshtein J, Feng F, Hamstra D. Johnson S, et al. Among authors: li d. Int J Radiat Oncol Biol Phys. 2013 Jul 1;86(3):554-61. doi: 10.1016/j.ijrobp.2013.02.016. Epub 2013 Apr 2. Int J Radiat Oncol Biol Phys. 2013. PMID: 23561650
A prostate-specific antigen doubling time of <6 months is prognostic for metastasis and prostate cancer-specific death for patients receiving salvage radiation therapy post radical prostatectomy.
Jackson WC, Johnson SB, Li D, Foster C, Foster B, Song Y, Schipper M, Shilkrut M, Sandler HM, Morgan TM, Palapattu GS, Hamstra DA, Feng FY. Jackson WC, et al. Among authors: li d. Radiat Oncol. 2013 Jul 8;8:170. doi: 10.1186/1748-717X-8-170. Radiat Oncol. 2013. PMID: 23835115 Free PMC article.
Larger maximum tumor diameter at radical prostatectomy is associated with increased biochemical failure, metastasis, and death from prostate cancer after salvage radiation for prostate cancer.
Johnson SB, Hamstra DA, Jackson WC, Zhou J, Foster B, Foster C, Song Y, Li D, Palapattu GS, Kunju L, Mehra R, Sandler H, Feng FY. Johnson SB, et al. Among authors: li d. Int J Radiat Oncol Biol Phys. 2013 Oct 1;87(2):275-81. doi: 10.1016/j.ijrobp.2013.05.043. Epub 2013 Jul 23. Int J Radiat Oncol Biol Phys. 2013. PMID: 23886418
Combining prostate-specific antigen nadir and time to nadir allows for early identification of patients at highest risk for development of metastasis and death following salvage radiation therapy.
Jackson WC, Johnson SB, Foster B, Foster C, Li D, Song Y, Vainshtein J, Zhou J, Hamstra DA, Feng FY. Jackson WC, et al. Among authors: li d. Pract Radiat Oncol. 2014 Mar-Apr;4(2):99-107. doi: 10.1016/j.prro.2013.05.008. Epub 2013 Jul 18. Pract Radiat Oncol. 2014. PMID: 24890350
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