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Binding of a single zinc ion to one subunit of copper-zinc superoxide dismutase apoprotein substantially influences the structure and stability of the entire homodimeric protein.
Potter SZ, Zhu H, Shaw BF, Rodriguez JA, Doucette PA, Sohn SH, Durazo A, Faull KF, Gralla EB, Nersissian AM, Valentine JS. Potter SZ, et al. Among authors: shaw bf. J Am Chem Soc. 2007 Apr 18;129(15):4575-83. doi: 10.1021/ja066690+. Epub 2007 Mar 24. J Am Chem Soc. 2007. PMID: 17381088
Loss of metal ions, disulfide reduction and mutations related to familial ALS promote formation of amyloid-like aggregates from superoxide dismutase.
Oztug Durer ZA, Cohlberg JA, Dinh P, Padua S, Ehrenclou K, Downes S, Tan JK, Nakano Y, Bowman CJ, Hoskins JL, Kwon C, Mason AZ, Rodriguez JA, Doucette PA, Shaw BF, Valentine JS. Oztug Durer ZA, et al. Among authors: shaw bf. PLoS One. 2009;4(3):e5004. doi: 10.1371/journal.pone.0005004. Epub 2009 Mar 27. PLoS One. 2009. PMID: 19325915 Free PMC article.
75 results