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P-glycoprotein retains drug-stimulated ATPase activity upon covalent linkage of the two nucleotide binding domains at their C-terminal ends.
Verhalen B, Wilkens S. Verhalen B, et al. Among authors: wilkens s. J Biol Chem. 2011 Mar 25;286(12):10476-82. doi: 10.1074/jbc.M110.193151. Epub 2011 Jan 28. J Biol Chem. 2011. PMID: 21278250 Free PMC article.
Y., Urbatsch, I. L., Senior, A. E., and Wilkens, S. (2002) J. Biol. Chem. 277, 40125-40131). Addition of nucleotide and/or substrate lead to a close association of the two halves of the transporter, thereby closing the central cavity (Lee, J. Y., Urbatsch, I. L., Se …
Y., Urbatsch, I. L., Senior, A. E., and Wilkens, S. (2002) J. Biol. Chem. 277, 40125-40131). Addition of nucleotide and/or sub …
Nucleotide-induced structural changes in P-glycoprotein observed by electron microscopy.
Lee JY, Urbatsch IL, Senior AE, Wilkens S. Lee JY, et al. Among authors: wilkens s. J Biol Chem. 2008 Feb 29;283(9):5769-79. doi: 10.1074/jbc.M707028200. Epub 2007 Dec 19. J Biol Chem. 2008. PMID: 18093977 Free article.
Y., Urbatsch, I. L., Senior, A. E., and Wilkens, S. (2002) J. Biol. Chem. 277, 40125-40131 ). Here we have analyzed the structure of cysteine-free human Pgp from two-dimensional crystals that were generated with the same lipid-monolayer technique in the absence and …
Y., Urbatsch, I. L., Senior, A. E., and Wilkens, S. (2002) J. Biol. Chem. 277, 40125-40131 ). Here we have analyzed the struct …
Structure and mechanism of ABC transporters.
Wilkens S. Wilkens S. F1000Prime Rep. 2015 Feb 3;7:14. doi: 10.12703/P7-14. eCollection 2015. F1000Prime Rep. 2015. PMID: 25750732 Free PMC article. Review.
150 results