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Heparanase promotes the spontaneous metastasis of myeloma cells to bone.
Yang Y, Macleod V, Bendre M, Huang Y, Theus AM, Miao HQ, Kussie P, Yaccoby S, Epstein J, Suva LJ, Kelly T, Sanderson RD. Yang Y, et al. Blood. 2005 Feb 1;105(3):1303-9. doi: 10.1182/blood-2004-06-2141. Epub 2004 Oct 7. Blood. 2005. PMID: 15471949 Free article.
The syndecan-1 heparan sulfate proteoglycan is a viable target for myeloma therapy.
Yang Y, MacLeod V, Dai Y, Khotskaya-Sample Y, Shriver Z, Venkataraman G, Sasisekharan R, Naggi A, Torri G, Casu B, Vlodavsky I, Suva LJ, Epstein J, Yaccoby S, Shaughnessy JD Jr, Barlogie B, Sanderson RD. Yang Y, et al. Blood. 2007 Sep 15;110(6):2041-8. doi: 10.1182/blood-2007-04-082495. Epub 2007 May 29. Blood. 2007. PMID: 17536013 Free PMC article.
Syndecan-1: a dynamic regulator of the myeloma microenvironment.
Sanderson RD, Yang Y. Sanderson RD, et al. Among authors: yang y. Clin Exp Metastasis. 2008;25(2):149-59. doi: 10.1007/s10585-007-9125-3. Epub 2007 Nov 20. Clin Exp Metastasis. 2008. PMID: 18027090 Free PMC article. Review.
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