Lepist EI - Search Results

1

Evaluation of the effect of cobicistat on the in vitro renal transport and cytotoxicity potential of tenofovir.

Stray KM, Bam RA, Birkus G, Hao J, Lepist EI, Yant SR, Ray AS, Cihlar T. Stray KM, et al. Among authors: lepist ei. Antimicrob Agents Chemother. 2013 Oct;57(10):4982-9. doi: 10.1128/AAC.00712-13. Epub 2013 Jul 29. Antimicrob Agents Chemother. 2013. PMID: 23896476 Free PMC article.

2

Renal drug-drug interactions: what we have learned and where we are going.

Lepist EI, Ray AS. Lepist EI, et al. Expert Opin Drug Metab Toxicol. 2012 Apr;8(4):433-48. doi: 10.1517/17425255.2012.667401. Epub 2012 Feb 29. Expert Opin Drug Metab Toxicol. 2012. PMID: 22372422 Review.

3

Cobicistat boosts the intestinal absorption of transport substrates, including HIV protease inhibitors and GS-7340, in vitro.

Lepist EI, Phan TK, Roy A, Tong L, Maclennan K, Murray B, Ray AS. Lepist EI, et al. Antimicrob Agents Chemother. 2012 Oct;56(10):5409-13. doi: 10.1128/AAC.01089-12. Epub 2012 Jul 30. Antimicrob Agents Chemother. 2012. PMID: 22850510 Free PMC article.

4

Pharmacokinetics of cobicistat boosted-elvitegravir administered in combination with rosuvastatin.

Custodio JM, Wang H, Hao J, Lepist EI, Ray AS, Andrews J, Ling KH, Cheng A, Kearney BP, Ramanathan S. Custodio JM, et al. Among authors: lepist ei. J Clin Pharmacol. 2014 Jun;54(6):649-56. doi: 10.1002/jcph.256. Epub 2014 Jan 17. J Clin Pharmacol. 2014. PMID: 24375014 Clinical Trial.

5

Metabolism and pharmacokinetics of the anti-hepatitis C virus nucleotide prodrug GS-6620.

Murakami E, Wang T, Babusis D, Lepist EI, Sauer D, Park Y, Vela JE, Shih R, Birkus G, Stefanidis D, Kim CU, Cho A, Ray AS. Murakami E, et al. Among authors: lepist ei. Antimicrob Agents Chemother. 2014;58(4):1943-51. doi: 10.1128/AAC.02350-13. Epub 2014 Jan 13. Antimicrob Agents Chemother. 2014. PMID: 24419340 Free PMC article.

6

Contribution of the organic anion transporter OAT2 to the renal active tubular secretion of creatinine and mechanism for serum creatinine elevations caused by cobicistat.

Lepist EI, Zhang X, Hao J, Huang J, Kosaka A, Birkus G, Murray BP, Bannister R, Cihlar T, Huang Y, Ray AS. Lepist EI, et al. Kidney Int. 2014 Aug;86(2):350-7. doi: 10.1038/ki.2014.66. Epub 2014 Mar 19. Kidney Int. 2014. PMID: 24646860 Free PMC article.

7

Implications of efficient hepatic delivery by tenofovir alafenamide (GS-7340) for hepatitis B virus therapy.

Murakami E, Wang T, Park Y, Hao J, Lepist EI, Babusis D, Ray AS. Murakami E, et al. Among authors: lepist ei. Antimicrob Agents Chemother. 2015;59(6):3563-9. doi: 10.1128/AAC.00128-15. Epub 2015 Apr 13. Antimicrob Agents Chemother. 2015. PMID: 25870059 Free PMC article.

8

Renal Transporter-Mediated Drug-Drug Interactions: Are They Clinically Relevant?

Lepist EI, Ray AS. Lepist EI, et al. J Clin Pharmacol. 2016 Jul;56 Suppl 7:S73-81. doi: 10.1002/jcph.735. J Clin Pharmacol. 2016. PMID: 27385181 Review.

9

Evaluation of the endothelin receptor antagonists ambrisentan, bosentan, macitentan, and sitaxsentan as hepatobiliary transporter inhibitors and substrates in sandwich-cultured human hepatocytes.

Lepist EI, Gillies H, Smith W, Hao J, Hubert C, St Claire RL 3rd, Brouwer KR, Ray AS. Lepist EI, et al. PLoS One. 2014 Jan 30;9(1):e87548. doi: 10.1371/journal.pone.0087548. eCollection 2014. PLoS One. 2014. PMID: 24498134 Free PMC article.

10

Beyond drug-drug interactions: effects of transporter inhibition on endobiotics, nutrients and toxins.

Lepist EI, Ray AS. Lepist EI, et al. Expert Opin Drug Metab Toxicol. 2017 Oct;13(10):1075-1087. doi: 10.1080/17425255.2017.1372425. Epub 2017 Aug 29. Expert Opin Drug Metab Toxicol. 2017. PMID: 28847160 Review.

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