Langouët S - Search Results

1

DNA adducts of the tobacco carcinogens 2-amino-9H-pyrido[2,3-b]indole and 4-aminobiphenyl are formed at environmental exposure levels and persist in human hepatocytes.

Nauwelaërs G, Bellamri M, Fessard V, Turesky RJ, Langouët S. Nauwelaërs G, et al. Among authors: langouet s. Chem Res Toxicol. 2013 Sep 16;26(9):1367-77. doi: 10.1021/tx4002226. Epub 2013 Aug 16. Chem Res Toxicol. 2013. PMID: 23898916 Free PMC article.

2

DNA adduct formation of 4-aminobiphenyl and heterocyclic aromatic amines in human hepatocytes.

Nauwelaers G, Bessette EE, Gu D, Tang Y, Rageul J, Fessard V, Yuan JM, Yu MC, Langouët S, Turesky RJ. Nauwelaers G, et al. Among authors: langouet s. Chem Res Toxicol. 2011 Jun 20;24(6):913-25. doi: 10.1021/tx200091y. Epub 2011 Apr 19. Chem Res Toxicol. 2011. PMID: 21456541 Free PMC article.

3

Mass Spectrometric Characterization of Human Serum Albumin Adducts Formed with N-Oxidized Metabolites of 2-Amino-1-methylphenylimidazo[4,5-b]pyridine in Human Plasma and Hepatocytes.

Wang Y, Peng L, Bellamri M, Langouët S, Turesky RJ. Wang Y, et al. Among authors: langouet s. Chem Res Toxicol. 2015 May 18;28(5):1045-59. doi: 10.1021/acs.chemrestox.5b00075. Epub 2015 Apr 10. Chem Res Toxicol. 2015. PMID: 25815793 Free PMC article.

4

2-Amino-9H-pyrido[2,3-b]indole (AαC) Adducts and Thiol Oxidation of Serum Albumin as Potential Biomarkers of Tobacco Smoke.

Pathak KV, Bellamri M, Wang Y, Langouët S, Turesky RJ. Pathak KV, et al. Among authors: langouet s. J Biol Chem. 2015 Jun 26;290(26):16304-18. doi: 10.1074/jbc.M115.646539. Epub 2015 May 7. J Biol Chem. 2015. PMID: 25953894 Free PMC article.

5

Human T lymphocytes bioactivate heterocyclic aromatic amines by forming DNA adducts.

Bellamri M, Le Hegarat L, Vernhet L, Baffet G, Turesky RJ, Langouët S. Bellamri M, et al. Among authors: langouet s. Environ Mol Mutagen. 2016 Dec;57(9):656-667. doi: 10.1002/em.22059. Epub 2016 Nov 1. Environ Mol Mutagen. 2016. PMID: 27801952 Free PMC article.

6

Metabolism of the Tobacco Carcinogen 2-Amino-9H-pyrido[2,3-b]indole (AαC) in Primary Human Hepatocytes.

Bellamri M, Le Hegarat L, Turesky RJ, Langouët S. Bellamri M, et al. Among authors: langouet s. Chem Res Toxicol. 2017 Feb 20;30(2):657-668. doi: 10.1021/acs.chemrestox.6b00394. Epub 2016 Dec 15. Chem Res Toxicol. 2017. PMID: 27976871 Free PMC article.

7

Metabolism of 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline in human hepatocytes: 2-amino-3-methylimidazo[4,5-f]quinoxaline-8-carboxylic acid is a major detoxification pathway catalyzed by cytochrome P450 1A2.

Langouët S, Welti DH, Kerriguy N, Fay LB, Huynh-Ba T, Markovic J, Guengerich FP, Guillouzo A, Turesky RJ. Langouët S, et al. Chem Res Toxicol. 2001 Feb;14(2):211-21. doi: 10.1021/tx000176e. Chem Res Toxicol. 2001. PMID: 11258970

8

DNA adducts of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine and 4-aminobiphenyl are infrequently detected in human mammary tissue by liquid chromatography/tandem mass spectrometry.

Gu D, Turesky RJ, Tao Y, Langouët SA, Nauwelaërs GC, Yuan JM, Yee D, Yu MC. Gu D, et al. Carcinogenesis. 2012 Jan;33(1):124-30. doi: 10.1093/carcin/bgr252. Epub 2011 Nov 9. Carcinogenesis. 2012. PMID: 22072616 Free PMC article.

9

Differential metabolism of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine in rat and human hepatocytes.

Langouët S, Paehler A, Welti DH, Kerriguy N, Guillouzo A, Turesky RJ. Langouët S, et al. Carcinogenesis. 2002 Jan;23(1):115-22. doi: 10.1093/carcin/23.1.115. Carcinogenesis. 2002. PMID: 11756232

10

UDP-glucuronosyltransferase-mediated metabolic activation of the tobacco carcinogen 2-amino-9H-pyrido[2,3-b]indole.

Tang Y, LeMaster DM, Nauwelaërs G, Gu D, Langouët S, Turesky RJ. Tang Y, et al. Among authors: langouet s. J Biol Chem. 2012 Apr 27;287(18):14960-72. doi: 10.1074/jbc.M111.320093. Epub 2012 Mar 5. J Biol Chem. 2012. PMID: 22393056 Free PMC article.

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