Schumacher WA - Search Results

1

Discovery of nonbenzamidine factor VIIa inhibitors using a biaryl acid scaffold.

Bolton SA, Sutton JC, Anumula R, Bisacchi GS, Jacobson B, Slusarchyk WA, Treuner UD, Wu SC, Zhao G, Pi Z, Sheriff S, Smirk RA, Bisaha S, Cheney DL, Wei A, Schumacher WA, Hartl KS, Liu E, Zahler R, Seiler SM. Bolton SA, et al. Among authors: schumacher wa. Bioorg Med Chem Lett. 2013 Sep 15;23(18):5239-43. doi: 10.1016/j.bmcl.2013.06.028. Epub 2013 Jun 20. Bioorg Med Chem Lett. 2013. PMID: 23927973

2

Pharmacological characterization of potent, long-acting thromboxane receptor antagonists, SQ 33,261 and SQ 33,552.

Harris DN, Michel IM, Goldenberg HJ, Hartl KS, Allen GT, Steinbacher TE, Schumacher WA, Han WC, Hall SE, Floyd DM, et al. Harris DN, et al. Among authors: schumacher wa. J Pharmacol Exp Ther. 1992 Apr;261(1):131-7. J Pharmacol Exp Ther. 1992. PMID: 1532833

3

Activity of the short-acting thromboxane receptor antagonist, SQ 30,741, in thrombolytic and vasospastic models in monkeys.

Schumacher WA, Heran CL, Hartl KS, Ogletree ML. Schumacher WA, et al. J Pharmacol Exp Ther. 1990 May;253(2):841-6. J Pharmacol Exp Ther. 1990. PMID: 2140131

4

Effect of a novel thrombin active-site inhibitor on arterial and venous thrombosis.

Schumacher WA, Balasubramanian N, St Laurent DR, Seiler SM. Schumacher WA, et al. Eur J Pharmacol. 1994 Jul 1;259(2):165-71. doi: 10.1016/0014-2999(94)90506-1. Eur J Pharmacol. 1994. PMID: 7957610

5

2-[3-[2-(4,5-diphenyl-2-oxazolyl) ethyl] phenoxy] acetic acid (BMY 42393): 2). Oral activity and efficacy in animal models of arterial thrombosis.

Seiler SM, Buchanan JO, Schumacher WA, Zavoico GB, Gamberdella M, Fleming JS, Meanwell NA. Seiler SM, et al. Among authors: schumacher wa. Thromb Res. 1994 Apr 15;74(2):125-33. doi: 10.1016/0049-3848(94)90005-1. Thromb Res. 1994. PMID: 8029813

6

Comparison of thrombin active site and exosite inhibitors and heparin in experimental models of arterial and venous thrombosis and bleeding.

Schumacher WA, Steinbacher TE, Heran CL, Seiler SM, Michel IM, Ogletree ML. Schumacher WA, et al. J Pharmacol Exp Ther. 1993 Dec;267(3):1237-42. J Pharmacol Exp Ther. 1993. PMID: 8263785

7

Active site-directed synthetic thrombin inhibitors: synthesis, in vitro and in vivo activity profile of BMY 44621 and analogs. An examination of the role of the amino group in the D-Phe-Pro-Arg-H series.

Balasubramanian N, St Laurent DR, Federici ME, Meanwell NA, Wright JJ, Schumacher WA, Seiler SM. Balasubramanian N, et al. Among authors: schumacher wa. J Med Chem. 1993 Jan 22;36(2):300-3. doi: 10.1021/jm00054a018. J Med Chem. 1993. PMID: 8423602 No abstract available.

8

Thrombin active site inhibitors: chemical synthesis, in vitro and in vivo pharmacological profile of a novel and selective agent BMS-189090 and analogues.

Das J, Kimball SD, Reid JA, Wang TC, Lau WF, Roberts DG, Seiler SM, Schumacher WA, Ogletree ML. Das J, et al. Among authors: schumacher wa. Bioorg Med Chem Lett. 2002 Jan 7;12(1):41-4. doi: 10.1016/s0960-894x(01)00664-3. Bioorg Med Chem Lett. 2002. PMID: 11738569

9

Molecular design and structure--activity relationships leading to the potent, selective, and orally active thrombin active site inhibitor BMS-189664.

Das J, Kimball SD, Hall SE, Han WC, Iwanowicz E, Lin J, Moquin RV, Reid JA, Sack JS, Malley MF, Chang CY, Chong S, Wang-Iverson DB, Roberts DG, Seiler SM, Schumacher WA, Ogletree ML. Das J, et al. Among authors: schumacher wa. Bioorg Med Chem Lett. 2002 Jan 7;12(1):45-9. doi: 10.1016/s0960-894x(01)00667-9. Bioorg Med Chem Lett. 2002. PMID: 11738570

10

Retro-binding thrombin active site inhibitors: identification of an orally active inhibitor of thrombin catalytic activity.

Iwanowicz EJ, Kimball SD, Lin J, Lau W, Han WC, Wang TC, Roberts DG, Schumacher WA, Ogletree ML, Seiler SM. Iwanowicz EJ, et al. Among authors: schumacher wa. Bioorg Med Chem Lett. 2002 Nov 4;12(21):3183-6. doi: 10.1016/s0960-894x(02)00651-0. Bioorg Med Chem Lett. 2002. PMID: 12372529

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