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GM-CSF as a therapeutic target in inflammatory diseases.
van Nieuwenhuijze A, Koenders M, Roeleveld D, Sleeman MA, van den Berg W, Wicks IP. van Nieuwenhuijze A, et al. Among authors: sleeman ma. Mol Immunol. 2013 Dec;56(4):675-82. doi: 10.1016/j.molimm.2013.05.002. Epub 2013 Aug 8. Mol Immunol. 2013. PMID: 23933508 Review.
Preclinical characterisation of the GM-CSF receptor as a therapeutic target in rheumatoid arthritis.
Greven DE, Cohen ES, Gerlag DM, Campbell J, Woods J, Davis N, van Nieuwenhuijze A, Lewis A, Heasmen S, McCourt M, Corkill D, Dodd A, Elvin J, Statache G, Wicks IP, Anderson IK, Nash A, Sleeman MA, Tak PP. Greven DE, et al. Among authors: sleeman ma. Ann Rheum Dis. 2015 Oct;74(10):1924-30. doi: 10.1136/annrheumdis-2014-205234. Epub 2014 Jun 16. Ann Rheum Dis. 2015. PMID: 24936585 Free PMC article.
Neutrophil GM-CSF receptor dynamics in acute lung injury.
De Alessandris S, Ferguson GJ, Dodd AJ, Juss JK, Devaprasad A, Piper S, Wyatt O, Killick H, Corkill DJ, Cohen ES, Pandit A, Radstake TRDJ, Simmonds R, Condliffe AM, Sleeman MA, Cowburn AS, Finch DK, Chilvers ER. De Alessandris S, et al. Among authors: sleeman ma. J Leukoc Biol. 2019 Jun;105(6):1183-1194. doi: 10.1002/JLB.3MA0918-347R. Epub 2019 Apr 3. J Leukoc Biol. 2019. PMID: 30942918 Free PMC article.
Targeting the GM-CSF receptor for the treatment of CNS autoimmunity.
Ifergan I, Davidson TS, Kebir H, Xu D, Palacios-Macapagal D, Cann J, Rodgers JM, Hunter ZN, Pittet CL, Beddow S, Jones CA, Prat A, Sleeman MA, Miller SD. Ifergan I, et al. Among authors: sleeman ma. J Autoimmun. 2017 Nov;84:1-11. doi: 10.1016/j.jaut.2017.06.005. Epub 2017 Jun 20. J Autoimmun. 2017. PMID: 28641926 Free PMC article.
A randomised phase IIb study of mavrilimumab, a novel GM-CSF receptor alpha monoclonal antibody, in the treatment of rheumatoid arthritis.
Burmester GR, McInnes IB, Kremer J, Miranda P, Korkosz M, Vencovsky J, Rubbert-Roth A, Mysler E, Sleeman MA, Godwood A, Sinibaldi D, Guo X, White WI, Wang B, Wu CY, Ryan PC, Close D, Weinblatt ME; EARTH EXPLORER 1 study investigators. Burmester GR, et al. Among authors: sleeman ma. Ann Rheum Dis. 2017 Jun;76(6):1020-1030. doi: 10.1136/annrheumdis-2016-210624. Epub 2017 Feb 17. Ann Rheum Dis. 2017. PMID: 28213566 Free article. Clinical Trial.
Mavrilimumab, a human monoclonal antibody targeting GM-CSF receptor-α, in subjects with rheumatoid arthritis: a randomised, double-blind, placebo-controlled, phase I, first-in-human study.
Burmester GR, Feist E, Sleeman MA, Wang B, White B, Magrini F. Burmester GR, et al. Among authors: sleeman ma. Ann Rheum Dis. 2011 Sep;70(9):1542-9. doi: 10.1136/ard.2010.146225. Epub 2011 May 25. Ann Rheum Dis. 2011. PMID: 21613310 Free PMC article. Clinical Trial.
107 results