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Acute tumour response to the MEK1/2 inhibitor selumetinib (AZD6244, ARRY-142886) evaluated by non-invasive diffusion-weighted MRI.
Beloueche-Babari M, Jamin Y, Arunan V, Walker-Samuel S, Revill M, Smith PD, Halliday J, Waterton JC, Barjat H, Workman P, Leach MO, Robinson SP. Beloueche-Babari M, et al. Among authors: arunan v. Br J Cancer. 2013 Sep 17;109(6):1562-9. doi: 10.1038/bjc.2013.456. Epub 2013 Aug 13. Br J Cancer. 2013. PMID: 23942066 Free PMC article.
Histone deacetylase inhibition increases levels of choline kinase α and phosphocholine facilitating noninvasive imaging in human cancers.
Beloueche-Babari M, Arunan V, Troy H, te Poele RH, te Fong AC, Jackson LE, Payne GS, Griffiths JR, Judson IR, Workman P, Leach MO, Chung YL. Beloueche-Babari M, et al. Among authors: arunan v. Cancer Res. 2012 Feb 15;72(4):990-1000. doi: 10.1158/0008-5472.CAN-11-2688. Epub 2011 Dec 22. Cancer Res. 2012. PMID: 22194463 Free PMC article.
MEK1/2 inhibition decreases lactate in BRAF-driven human cancer cells.
Falck Miniotis M, Arunan V, Eykyn TR, Marais R, Workman P, Leach MO, Beloueche-Babari M. Falck Miniotis M, et al. Among authors: arunan v. Cancer Res. 2013 Jul 1;73(13):4039-49. doi: 10.1158/0008-5472.CAN-12-1969. Epub 2013 May 2. Cancer Res. 2013. PMID: 23639941 Free article.
MCT1 Inhibitor AZD3965 Increases Mitochondrial Metabolism, Facilitating Combination Therapy and Noninvasive Magnetic Resonance Spectroscopy.
Beloueche-Babari M, Wantuch S, Casals Galobart T, Koniordou M, Parkes HG, Arunan V, Chung YL, Eykyn TR, Smith PD, Leach MO. Beloueche-Babari M, et al. Among authors: arunan v. Cancer Res. 2017 Nov 1;77(21):5913-5924. doi: 10.1158/0008-5472.CAN-16-2686. Epub 2017 Sep 18. Cancer Res. 2017. PMID: 28923861 Free PMC article.