Werz O - Search Results

1

Coordinate functional regulation between microsomal prostaglandin E synthase-1 (mPGES-1) and peroxisome proliferator-activated receptor γ (PPARγ) in the conversion of white-to-brown adipocytes.

García-Alonso V, López-Vicario C, Titos E, Morán-Salvador E, González-Périz A, Rius B, Párrizas M, Werz O, Arroyo V, Clària J. García-Alonso V, et al. Among authors: werz o. J Biol Chem. 2013 Sep 27;288(39):28230-42. doi: 10.1074/jbc.M113.468603. Epub 2013 Aug 13. J Biol Chem. 2013. PMID: 23943621 Free PMC article.

2

Pharmacophore modeling and virtual screening for novel acidic inhibitors of microsomal prostaglandin E₂ synthase-1 (mPGES-1).

Waltenberger B, Wiechmann K, Bauer J, Markt P, Noha SM, Wolber G, Rollinger JM, Werz O, Schuster D, Stuppner H. Waltenberger B, et al. Among authors: werz o. J Med Chem. 2011 May 12;54(9):3163-74. doi: 10.1021/jm101309g. Epub 2011 Apr 20. J Med Chem. 2011. PMID: 21466167 Free PMC article.

3

Pirinixic acid derivatives as novel dual inhibitors of microsomal prostaglandin E2 synthase-1 and 5-lipoxygenase.

Koeberle A, Zettl H, Greiner C, Wurglics M, Schubert-Zsilavecz M, Werz O. Koeberle A, et al. Among authors: werz o. J Med Chem. 2008 Dec 25;51(24):8068-76. doi: 10.1021/jm801085s. J Med Chem. 2008. PMID: 19053751

4

Arylpyrrolizines as inhibitors of microsomal prostaglandin E2 synthase-1 (mPGES-1) or as dual inhibitors of mPGES-1 and 5-lipoxygenase (5-LOX).

Liedtke AJ, Keck PR, Lehmann F, Koeberle A, Werz O, Laufer SA. Liedtke AJ, et al. Among authors: werz o. J Med Chem. 2009 Aug 13;52(15):4968-72. doi: 10.1021/jm900481c. J Med Chem. 2009. PMID: 19719242

5

Discovery of benzo[g]indol-3-carboxylates as potent inhibitors of microsomal prostaglandin E(2) synthase-1.

Koeberle A, Haberl EM, Rossi A, Pergola C, Dehm F, Northoff H, Troschuetz R, Sautebin L, Werz O. Koeberle A, et al. Among authors: werz o. Bioorg Med Chem. 2009 Dec 1;17(23):7924-32. doi: 10.1016/j.bmc.2009.10.025. Epub 2009 Oct 31. Bioorg Med Chem. 2009. PMID: 19884011

6

Structure-based discovery of inhibitors of microsomal prostaglandin E2 synthase-1, 5-lipoxygenase and 5-lipoxygenase-activating protein: promising hits for the development of new anti-inflammatory agents.

De Simone R, Chini MG, Bruno I, Riccio R, Mueller D, Werz O, Bifulco G. De Simone R, et al. Among authors: werz o. J Med Chem. 2011 Mar 24;54(6):1565-75. doi: 10.1021/jm101238d. Epub 2011 Feb 16. J Med Chem. 2011. PMID: 21323313

7

Identification of 2-mercaptohexanoic acids as dual inhibitors of 5-lipoxygenase and microsomal prostaglandin E₂ synthase-1.

Greiner C, Zettl H, Koeberle A, Pergola C, Northoff H, Schubert-Zsilavecz M, Werz O. Greiner C, et al. Among authors: werz o. Bioorg Med Chem. 2011 Jun 1;19(11):3394-401. doi: 10.1016/j.bmc.2011.04.034. Epub 2011 Apr 22. Bioorg Med Chem. 2011. PMID: 21570310

8

Aminothiazole-featured pirinixic acid derivatives as dual 5-lipoxygenase and microsomal prostaglandin E2 synthase-1 inhibitors with improved potency and efficiency in vivo.

Hanke T, Dehm F, Liening S, Popella SD, Maczewsky J, Pillong M, Kunze J, Weinigel C, Barz D, Kaiser A, Wurglics M, Lämmerhofer M, Schneider G, Sautebin L, Schubert-Zsilavecz M, Werz O. Hanke T, et al. Among authors: werz o. J Med Chem. 2013 Nov 27;56(22):9031-44. doi: 10.1021/jm401557w. Epub 2013 Nov 15. J Med Chem. 2013. PMID: 24171493

9

Exploration of the dihydropyrimidine scaffold for the development of new potential anti-inflammatory agents blocking prostaglandin E₂ synthase-1 enzyme (mPGES-1).

Lauro G, Strocchia M, Terracciano S, Bruno I, Fischer K, Pergola C, Werz O, Riccio R, Bifulco G. Lauro G, et al. Among authors: werz o. Eur J Med Chem. 2014 Jun 10;80:407-15. doi: 10.1016/j.ejmech.2014.04.061. Epub 2014 Apr 24. Eur J Med Chem. 2014. PMID: 24794772

10

Discovery of novel, non-acidic mPGES-1 inhibitors by virtual screening with a multistep protocol.

Noha SM, Fischer K, Koeberle A, Garscha U, Werz O, Schuster D. Noha SM, et al. Among authors: werz o. Bioorg Med Chem. 2015 Aug 1;23(15):4839-4845. doi: 10.1016/j.bmc.2015.05.045. Epub 2015 Jun 1. Bioorg Med Chem. 2015. PMID: 26088337 Free PMC article.

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