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Interleukin-11 is the dominant IL-6 family cytokine during gastrointestinal tumorigenesis and can be targeted therapeutically.
Putoczki TL, Thiem S, Loving A, Busuttil RA, Wilson NJ, Ziegler PK, Nguyen PM, Preaudet A, Farid R, Edwards KM, Boglev Y, Luwor RB, Jarnicki A, Horst D, Boussioutas A, Heath JK, Sieber OM, Pleines I, Kile BT, Nash A, Greten FR, McKenzie BS, Ernst M. Putoczki TL, et al. Among authors: greten fr. Cancer Cell. 2013 Aug 12;24(2):257-71. doi: 10.1016/j.ccr.2013.06.017. Cancer Cell. 2013. PMID: 23948300 Free article.
Combining ferroptosis induction with MDSC blockade renders primary tumours and metastases in liver sensitive to immune checkpoint blockade.
Conche C, Finkelmeier F, Pešić M, Nicolas AM, Böttger TW, Kennel KB, Denk D, Ceteci F, Mohs K, Engel E, Canli Ö, Dabiri Y, Peiffer KH, Zeuzem S, Salinas G, Longerich T, Yang H, Greten FR. Conche C, et al. Among authors: greten fr. Gut. 2023 Sep;72(9):1774-1782. doi: 10.1136/gutjnl-2022-327909. Epub 2023 Jan 27. Gut. 2023. PMID: 36707233 Free PMC article.
Colon tumour cell death causes mTOR dependence by paracrine P2X4 stimulation.
Schmitt M, Ceteci F, Gupta J, Pesic M, Böttger TW, Nicolas AM, Kennel KB, Engel E, Schewe M, Callak Kirisözü A, Petrocelli V, Dabiri Y, Varga J, Ramakrishnan M, Karimova M, Ablasser A, Sato T, Arkan MC, de Sauvage FJ, Greten FR. Schmitt M, et al. Among authors: greten fr. Nature. 2022 Dec;612(7939):347-353. doi: 10.1038/s41586-022-05426-1. Epub 2022 Nov 16. Nature. 2022. PMID: 36385525 Free PMC article.
gp130-mediated Stat3 activation in enterocytes regulates cell survival and cell-cycle progression during colitis-associated tumorigenesis.
Bollrath J, Phesse TJ, von Burstin VA, Putoczki T, Bennecke M, Bateman T, Nebelsiek T, Lundgren-May T, Canli O, Schwitalla S, Matthews V, Schmid RM, Kirchner T, Arkan MC, Ernst M, Greten FR. Bollrath J, et al. Among authors: greten fr. Cancer Cell. 2009 Feb 3;15(2):91-102. doi: 10.1016/j.ccr.2009.01.002. Cancer Cell. 2009. PMID: 19185844 Free article.
Loss of p53 in enterocytes generates an inflammatory microenvironment enabling invasion and lymph node metastasis of carcinogen-induced colorectal tumors.
Schwitalla S, Ziegler PK, Horst D, Becker V, Kerle I, Begus-Nahrmann Y, Lechel A, Rudolph KL, Langer R, Slotta-Huspenina J, Bader FG, Prazeres da Costa O, Neurath MF, Meining A, Kirchner T, Greten FR. Schwitalla S, et al. Among authors: greten fr. Cancer Cell. 2013 Jan 14;23(1):93-106. doi: 10.1016/j.ccr.2012.11.014. Epub 2012 Dec 27. Cancer Cell. 2013. PMID: 23273920 Free article.
Intestinal tumorigenesis initiated by dedifferentiation and acquisition of stem-cell-like properties.
Schwitalla S, Fingerle AA, Cammareri P, Nebelsiek T, Göktuna SI, Ziegler PK, Canli O, Heijmans J, Huels DJ, Moreaux G, Rupec RA, Gerhard M, Schmid R, Barker N, Clevers H, Lang R, Neumann J, Kirchner T, Taketo MM, van den Brink GR, Sansom OJ, Arkan MC, Greten FR. Schwitalla S, et al. Among authors: greten fr. Cell. 2013 Jan 17;152(1-2):25-38. doi: 10.1016/j.cell.2012.12.012. Epub 2012 Dec 27. Cell. 2013. PMID: 23273993 Free article.
IKKα promotes intestinal tumorigenesis by limiting recruitment of M1-like polarized myeloid cells.
Göktuna SI, Canli O, Bollrath J, Fingerle AA, Horst D, Diamanti MA, Pallangyo C, Bennecke M, Nebelsiek T, Mankan AK, Lang R, Artis D, Hu Y, Patzelt T, Ruland J, Kirchner T, Taketo MM, Chariot A, Arkan MC, Greten FR. Göktuna SI, et al. Among authors: greten fr. Cell Rep. 2014 Jun 26;7(6):1914-25. doi: 10.1016/j.celrep.2014.05.006. Epub 2014 May 29. Cell Rep. 2014. PMID: 24882009 Free PMC article.
124 results