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Interleukin-11 is the dominant IL-6 family cytokine during gastrointestinal tumorigenesis and can be targeted therapeutically.
Putoczki TL, Thiem S, Loving A, Busuttil RA, Wilson NJ, Ziegler PK, Nguyen PM, Preaudet A, Farid R, Edwards KM, Boglev Y, Luwor RB, Jarnicki A, Horst D, Boussioutas A, Heath JK, Sieber OM, Pleines I, Kile BT, Nash A, Greten FR, McKenzie BS, Ernst M. Putoczki TL, et al. Among authors: horst d. Cancer Cell. 2013 Aug 12;24(2):257-71. doi: 10.1016/j.ccr.2013.06.017. Cancer Cell. 2013. PMID: 23948300 Free article.
Loss of p53 in enterocytes generates an inflammatory microenvironment enabling invasion and lymph node metastasis of carcinogen-induced colorectal tumors.
Schwitalla S, Ziegler PK, Horst D, Becker V, Kerle I, Begus-Nahrmann Y, Lechel A, Rudolph KL, Langer R, Slotta-Huspenina J, Bader FG, Prazeres da Costa O, Neurath MF, Meining A, Kirchner T, Greten FR. Schwitalla S, et al. Among authors: horst d. Cancer Cell. 2013 Jan 14;23(1):93-106. doi: 10.1016/j.ccr.2012.11.014. Epub 2012 Dec 27. Cancer Cell. 2013. PMID: 23273920 Free article.
IKKα promotes intestinal tumorigenesis by limiting recruitment of M1-like polarized myeloid cells.
Göktuna SI, Canli O, Bollrath J, Fingerle AA, Horst D, Diamanti MA, Pallangyo C, Bennecke M, Nebelsiek T, Mankan AK, Lang R, Artis D, Hu Y, Patzelt T, Ruland J, Kirchner T, Taketo MM, Chariot A, Arkan MC, Greten FR. Göktuna SI, et al. Among authors: horst d. Cell Rep. 2014 Jun 26;7(6):1914-25. doi: 10.1016/j.celrep.2014.05.006. Epub 2014 May 29. Cell Rep. 2014. PMID: 24882009 Free PMC article.
ADNP Is a Therapeutically Inducible Repressor of WNT Signaling in Colorectal Cancer.
Blaj C, Bringmann A, Schmidt EM, Urbischek M, Lamprecht S, Fröhlich T, Arnold GJ, Krebs S, Blum H, Hermeking H, Jung A, Kirchner T, Horst D. Blaj C, et al. Among authors: horst d. Clin Cancer Res. 2017 Jun 1;23(11):2769-2780. doi: 10.1158/1078-0432.CCR-16-1604. Epub 2016 Nov 30. Clin Cancer Res. 2017. PMID: 27903678
Myeloid Cell-Derived Reactive Oxygen Species Induce Epithelial Mutagenesis.
Canli Ö, Nicolas AM, Gupta J, Finkelmeier F, Goncharova O, Pesic M, Neumann T, Horst D, Löwer M, Sahin U, Greten FR. Canli Ö, et al. Among authors: horst d. Cancer Cell. 2017 Dec 11;32(6):869-883.e5. doi: 10.1016/j.ccell.2017.11.004. Cancer Cell. 2017. PMID: 29232557 Free article.
Mitophagy in Intestinal Epithelial Cells Triggers Adaptive Immunity during Tumorigenesis.
Ziegler PK, Bollrath J, Pallangyo CK, Matsutani T, Canli Ö, De Oliveira T, Diamanti MA, Müller N, Gamrekelashvili J, Putoczki T, Horst D, Mankan AK, Öner MG, Müller S, Müller-Höcker J, Kirchner T, Slotta-Huspenina J, Taketo MM, Reinheckel T, Dröse S, Larner AC, Wels WS, Ernst M, Greten TF, Arkan MC, Korn T, Wirth D, Greten FR. Ziegler PK, et al. Among authors: horst d. Cell. 2018 Jun 28;174(1):88-101.e16. doi: 10.1016/j.cell.2018.05.028. Epub 2018 Jun 14. Cell. 2018. PMID: 29909986 Free PMC article.
Olfactomedin 4 associates with expression of differentiation markers but not with properties of cancer stemness, EMT nor metastatic spread in colorectal cancer.
Jaitner S, Pretzsch E, Neumann J, Schäffauer A, Schiemann M, Angele M, Kumbrink J, Schwitalla S, Greten FR, Brandl L, Klauschen F, Horst D, Kirchner T, Jung A. Jaitner S, et al. Among authors: horst d. J Pathol Clin Res. 2023 Jan;9(1):73-85. doi: 10.1002/cjp2.300. Epub 2022 Nov 8. J Pathol Clin Res. 2023. PMID: 36349502 Free PMC article.
370 results