Lin TH - Search Results

1

Utility of physiologically based modeling and preclinical in vitro/in vivo data to mitigate positive food effect in a BCS class 2 compound.

Xia B, Heimbach T, Lin TH, Li S, Zhang H, Sheng J, He H. Xia B, et al. Among authors: lin th. AAPS PharmSciTech. 2013 Sep;14(3):1255-66. doi: 10.1208/s12249-013-0018-2. Epub 2013 Aug 17. AAPS PharmSciTech. 2013. PMID: 23955148 Free PMC article. Clinical Trial.

2

Novel physiologically based pharmacokinetic modeling of patupilone for human pharmacokinetic predictions.

Xia B, Heimbach T, Lin TH, He H, Wang Y, Tan E. Xia B, et al. Among authors: lin th. Cancer Chemother Pharmacol. 2012 Jun;69(6):1567-82. doi: 10.1007/s00280-012-1863-5. Epub 2012 Apr 11. Cancer Chemother Pharmacol. 2012. PMID: 22526410

3

Nilotinib preclinical pharmacokinetics and practical application toward clinical projections of oral absorption and systemic availability.

Xia B, Heimbach T, He H, Lin TH. Xia B, et al. Among authors: lin th. Biopharm Drug Dispos. 2012 Dec;33(9):536-49. doi: 10.1002/bdd.1821. Epub 2012 Nov 19. Biopharm Drug Dispos. 2012. PMID: 23097199

4

Case studies for practical food effect assessments across BCS/BDDCS class compounds using in silico, in vitro, and preclinical in vivo data.

Heimbach T, Xia B, Lin TH, He H. Heimbach T, et al. Among authors: lin th. AAPS J. 2013 Jan;15(1):143-58. doi: 10.1208/s12248-012-9419-5. Epub 2012 Nov 10. AAPS J. 2013. PMID: 23139017 Free PMC article.

5

Application of physiologically based absorption modeling to formulation development of a low solubility, low permeability weak base: mechanistic investigation of food effect.

Zhang H, Xia B, Sheng J, Heimbach T, Lin TH, He H, Wang Y, Novick S, Comfort A. Zhang H, et al. Among authors: lin th. AAPS PharmSciTech. 2014 Apr;15(2):400-6. doi: 10.1208/s12249-014-0075-1. Epub 2014 Jan 17. AAPS PharmSciTech. 2014. PMID: 24435225 Free PMC article.

6

Evaluation of Drug-Drug Interaction Potential Between Sacubitril/Valsartan (LCZ696) and Statins Using a Physiologically Based Pharmacokinetic Model.

Lin W, Ji T, Einolf H, Ayalasomayajula S, Lin TH, Hanna I, Heimbach T, Breen C, Jarugula V, He H. Lin W, et al. Among authors: lin th. J Pharm Sci. 2017 May;106(5):1439-1451. doi: 10.1016/j.xphs.2017.01.007. Epub 2017 Jan 13. J Pharm Sci. 2017. PMID: 28089685

7

Pharmacokinetics and pharmacodynamics of LCZ696, a novel dual-acting angiotensin receptor-neprilysin inhibitor (ARNi).

Gu J, Noe A, Chandra P, Al-Fayoumi S, Ligueros-Saylan M, Sarangapani R, Maahs S, Ksander G, Rigel DF, Jeng AY, Lin TH, Zheng W, Dole WP. Gu J, et al. Among authors: lin th. J Clin Pharmacol. 2010 Apr;50(4):401-14. doi: 10.1177/0091270009343932. Epub 2009 Nov 23. J Clin Pharmacol. 2010. PMID: 19934029 Clinical Trial.

8

Osilodrostat (LCI699), a potent 11β-hydroxylase inhibitor, administered in combination with the multireceptor-targeted somatostatin analog pasireotide: A 13-week study in rats.

Li L, Vashisht K, Boisclair J, Li W, Lin TH, Schmid HA, Kluwe W, Schoenfeld H, Hoffmann P. Li L, et al. Among authors: lin th. Toxicol Appl Pharmacol. 2015 Aug 1;286(3):224-33. doi: 10.1016/j.taap.2015.05.004. Epub 2015 May 14. Toxicol Appl Pharmacol. 2015. PMID: 25981165 Free article.

9

Effect of Renal Impairment on the Pharmacokinetics of Pradigastat, a Novel Diacylglycerol Acyltransferase1 (DGAT1) Inhibitor.

Mita S, Meyers D, Pal P, Lin T, Majumdar T, Rebello S, Sunkara G, Chen J. Mita S, et al. Clin Pharmacokinet. 2015 Jul;54(7):751-60. doi: 10.1007/s40262-015-0234-x. Clin Pharmacokinet. 2015. PMID: 25627776 Clinical Trial.

10

Effect of Hepatic Impairment on the Pharmacokinetics of Pradigastat, a Diacylglycerol Acyltransferase 1 (DGAT1) Inhibitor.

Hirano M, Meyers D, Golla G, Pal P, Pinot P, Lin T, Majumdar T, Rebello S, Sunkara G, Chen J. Hirano M, et al. Clin Pharmacokinet. 2015 Jul;54(7):761-70. doi: 10.1007/s40262-015-0235-9. Clin Pharmacokinet. 2015. PMID: 25633714 Clinical Trial.

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