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CHIP and Hsp70 regulate tau ubiquitination, degradation and aggregation.
Petrucelli L, Dickson D, Kehoe K, Taylor J, Snyder H, Grover A, De Lucia M, McGowan E, Lewis J, Prihar G, Kim J, Dillmann WH, Browne SE, Hall A, Voellmy R, Tsuboi Y, Dawson TM, Wolozin B, Hardy J, Hutton M. Petrucelli L, et al. Hum Mol Genet. 2004 Apr 1;13(7):703-14. doi: 10.1093/hmg/ddh083. Epub 2004 Feb 12. Hum Mol Genet. 2004. PMID: 14962978
Deletion of the ubiquitin ligase CHIP leads to the accumulation, but not the aggregation, of both endogenous phospho- and caspase-3-cleaved tau species.
Dickey CA, Yue M, Lin WL, Dickson DW, Dunmore JH, Lee WC, Zehr C, West G, Cao S, Clark AM, Caldwell GA, Caldwell KA, Eckman C, Patterson C, Hutton M, Petrucelli L. Dickey CA, et al. Among authors: petrucelli l. J Neurosci. 2006 Jun 28;26(26):6985-96. doi: 10.1523/JNEUROSCI.0746-06.2006. J Neurosci. 2006. PMID: 16807328 Free PMC article.
Brain CHIP: removing the culprits in neurodegenerative disease.
Dickey CA, Patterson C, Dickson D, Petrucelli L. Dickey CA, et al. Among authors: petrucelli l. Trends Mol Med. 2007 Jan;13(1):32-8. doi: 10.1016/j.molmed.2006.11.003. Epub 2006 Nov 28. Trends Mol Med. 2007. PMID: 17127096 Review.
The high-affinity HSP90-CHIP complex recognizes and selectively degrades phosphorylated tau client proteins.
Dickey CA, Kamal A, Lundgren K, Klosak N, Bailey RM, Dunmore J, Ash P, Shoraka S, Zlatkovic J, Eckman CB, Patterson C, Dickson DW, Nahman NS Jr, Hutton M, Burrows F, Petrucelli L. Dickey CA, et al. Among authors: petrucelli l. J Clin Invest. 2007 Mar;117(3):648-58. doi: 10.1172/JCI29715. Epub 2007 Feb 15. J Clin Invest. 2007. PMID: 17304350 Free PMC article.
Progranulin mediates caspase-dependent cleavage of TAR DNA binding protein-43.
Zhang YJ, Xu YF, Dickey CA, Buratti E, Baralle F, Bailey R, Pickering-Brown S, Dickson D, Petrucelli L. Zhang YJ, et al. Among authors: petrucelli l. J Neurosci. 2007 Sep 26;27(39):10530-4. doi: 10.1523/JNEUROSCI.3421-07.2007. J Neurosci. 2007. PMID: 17898224 Free PMC article.
TDP-43 in neurodegenerative disorders.
Cook C, Zhang YJ, Xu YF, Dickson DW, Petrucelli L. Cook C, et al. Among authors: petrucelli l. Expert Opin Biol Ther. 2008 Jul;8(7):969-78. doi: 10.1517/14712598.8.7.969. Expert Opin Biol Ther. 2008. PMID: 18549326 Free PMC article. Review.
331 results