Lelay J - Search Results

1

Increased hippocampal neurogenesis and accelerated response to antidepressants in mice with specific deletion of CREB in the hippocampus: role of cAMP response-element modulator τ.

Gundersen BB, Briand LA, Onksen JL, Lelay J, Kaestner KH, Blendy JA. Gundersen BB, et al. Among authors: lelay j. J Neurosci. 2013 Aug 21;33(34):13673-85. doi: 10.1523/JNEUROSCI.1669-13.2013. J Neurosci. 2013. PMID: 23966689 Free PMC article.

2

The transcription factor CREB has no non-redundant functions in hepatic glucose metabolism in mice.

Lee D, Le Lay J, Kaestner KH. Lee D, et al. Diabetologia. 2014 Jun;57(6):1242-8. doi: 10.1007/s00125-014-3203-2. Epub 2014 Mar 5. Diabetologia. 2014. PMID: 24595858

3

Serine 133 phosphorylation is not required for hippocampal CREB-mediated transcription and behavior.

Briand LA, Lee BG, Lelay J, Kaestner KH, Blendy JA. Briand LA, et al. Among authors: lelay j. Learn Mem. 2015 Jan 15;22(2):109-15. doi: 10.1101/lm.037044.114. Print 2015 Feb. Learn Mem. 2015. PMID: 25593297 Free PMC article.

4

Integrative genomic analysis of CREB defines a critical role for transcription factor networks in mediating the fed/fasted switch in liver.

Everett LJ, Le Lay J, Lukovac S, Bernstein D, Steger DJ, Lazar MA, Kaestner KH. Everett LJ, et al. BMC Genomics. 2013 May 17;14:337. doi: 10.1186/1471-2164-14-337. BMC Genomics. 2013. PMID: 23682854 Free PMC article.

5

CISH has no non-redundant functions in glucose homeostasis or beta cell proliferation during pregnancy in mice.

Jiao Y, Rieck S, Le Lay J, Kaestner KH. Jiao Y, et al. Diabetologia. 2013 Nov;56(11):2435-45. doi: 10.1007/s00125-013-3014-x. Epub 2013 Aug 16. Diabetologia. 2013. PMID: 23949579 Free PMC article.

6

CREB mediates the insulinotropic and anti-apoptotic effects of GLP-1 signaling in adult mouse β-cells.

Shin S, Le Lay J, Everett LJ, Gupta R, Rafiq K, Kaestner KH. Shin S, et al. Mol Metab. 2014 Aug 23;3(8):803-12. doi: 10.1016/j.molmet.2014.08.001. eCollection 2014 Nov. Mol Metab. 2014. PMID: 25379405 Free PMC article.

7

The CREB/CRTC2 pathway modulates autoimmune disease by promoting Th17 differentiation.

Hernandez JB, Chang C, LeBlanc M, Grimm D, Le Lay J, Kaestner KH, Zheng Y, Montminy M. Hernandez JB, et al. Nat Commun. 2015 Jun 2;6:7216. doi: 10.1038/ncomms8216. Nat Commun. 2015. PMID: 26031354 Free PMC article.

8

CREB pathway links PGE2 signaling with macrophage polarization.

Luan B, Yoon YS, Le Lay J, Kaestner KH, Hedrick S, Montminy M. Luan B, et al. Proc Natl Acad Sci U S A. 2015 Dec 22;112(51):15642-7. doi: 10.1073/pnas.1519644112. Epub 2015 Dec 7. Proc Natl Acad Sci U S A. 2015. PMID: 26644581 Free PMC article.

9

CREB coactivators CRTC2 and CRTC3 modulate bone marrow hematopoiesis.

Kim JH, Hedrick S, Tsai WW, Wiater E, Le Lay J, Kaestner KH, Leblanc M, Loar A, Montminy M. Kim JH, et al. Proc Natl Acad Sci U S A. 2017 Oct 31;114(44):11739-11744. doi: 10.1073/pnas.1712616114. Epub 2017 Oct 16. Proc Natl Acad Sci U S A. 2017. PMID: 29078378 Free PMC article.

10

CRTC2 (TORC2) contributes to the transcriptional response to fasting in the liver but is not required for the maintenance of glucose homeostasis.

Le Lay J, Tuteja G, White P, Dhir R, Ahima R, Kaestner KH. Le Lay J, et al. Cell Metab. 2009 Jul;10(1):55-62. doi: 10.1016/j.cmet.2009.06.006. Cell Metab. 2009. PMID: 19583954 Free PMC article.

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