Cacho RA - Search Results

1

Complexity generation in fungal polyketide biosynthesis: a spirocycle-forming P450 in the concise pathway to the antifungal drug griseofulvin.

Cacho RA, Chooi YH, Zhou H, Tang Y. Cacho RA, et al. ACS Chem Biol. 2013 Oct 18;8(10):2322-30. doi: 10.1021/cb400541z. Epub 2013 Sep 9. ACS Chem Biol. 2013. PMID: 23978092 Free PMC article.

2

Directed evolution and structural characterization of a simvastatin synthase.

Gao X, Xie X, Pashkov I, Sawaya MR, Laidman J, Zhang W, Cacho R, Yeates TO, Tang Y. Gao X, et al. Chem Biol. 2009 Oct 30;16(10):1064-74. doi: 10.1016/j.chembiol.2009.09.017. Chem Biol. 2009. PMID: 19875080 Free PMC article.

3

Identification of the viridicatumtoxin and griseofulvin gene clusters from Penicillium aethiopicum.

Chooi YH, Cacho R, Tang Y. Chooi YH, et al. Chem Biol. 2010 May 28;17(5):483-94. doi: 10.1016/j.chembiol.2010.03.015. Chem Biol. 2010. PMID: 20534346 Free PMC article.

4

Protein engineering towards natural product synthesis and diversification.

Zabala AO, Cacho RA, Tang Y. Zabala AO, et al. Among authors: cacho ra. J Ind Microbiol Biotechnol. 2012 Feb;39(2):227-41. doi: 10.1007/s10295-011-1044-2. Epub 2011 Oct 18. J Ind Microbiol Biotechnol. 2012. PMID: 22006344 Free PMC article. Review.

5

Identification and characterization of the echinocandin B biosynthetic gene cluster from Emericella rugulosa NRRL 11440.

Cacho RA, Jiang W, Chooi YH, Walsh CT, Tang Y. Cacho RA, et al. J Am Chem Soc. 2012 Oct 10;134(40):16781-90. doi: 10.1021/ja307220z. Epub 2012 Oct 1. J Am Chem Soc. 2012. PMID: 22998630 Free PMC article.

6

Bringing protein engineering and natural product biosynthesis together.

Cacho RA, Tang Y. Cacho RA, et al. Chem Biol. 2013 Jan 24;20(1):3-5. doi: 10.1016/j.chembiol.2013.01.005. Chem Biol. 2013. PMID: 23352133

7

EcdGHK are three tailoring iron oxygenases for amino acid building blocks of the echinocandin scaffold.

Jiang W, Cacho RA, Chiou G, Garg NK, Tang Y, Walsh CT. Jiang W, et al. Among authors: cacho ra. J Am Chem Soc. 2013 Mar 20;135(11):4457-66. doi: 10.1021/ja312572v. Epub 2013 Mar 11. J Am Chem Soc. 2013. PMID: 23451921 Free PMC article.

8

Discovery of cryptic polyketide metabolites from dermatophytes using heterologous expression in Aspergillus nidulans.

Yin WB, Chooi YH, Smith AR, Cacho RA, Hu Y, White TC, Tang Y. Yin WB, et al. Among authors: cacho ra. ACS Synth Biol. 2013 Nov 15;2(11):629-34. doi: 10.1021/sb400048b. Epub 2013 Jun 11. ACS Synth Biol. 2013. PMID: 23758576 Free PMC article.

9

A cytochrome P450 serves as an unexpected terpene cyclase during fungal meroterpenoid biosynthesis.

Chooi YH, Hong YJ, Cacho RA, Tantillo DJ, Tang Y. Chooi YH, et al. Among authors: cacho ra. J Am Chem Soc. 2013 Nov 13;135(45):16805-8. doi: 10.1021/ja408966t. Epub 2013 Nov 1. J Am Chem Soc. 2013. PMID: 24161266 Free PMC article.

10

Next-generation sequencing approach for connecting secondary metabolites to biosynthetic gene clusters in fungi.

Cacho RA, Tang Y, Chooi YH. Cacho RA, et al. Front Microbiol. 2015 Jan 14;5:774. doi: 10.3389/fmicb.2014.00774. eCollection 2014. Front Microbiol. 2015. PMID: 25642215 Free PMC article. Review.

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