Czechtizky W - Search Results

1

Evaluation of cancer dependence and druggability of PRP4 kinase using cellular, biochemical, and structural approaches.

Gao Q, Mechin I, Kothari N, Guo Z, Deng G, Haas K, McManus J, Hoffmann D, Wang A, Wiederschain D, Rocnik J, Czechtizky W, Chen X, McLean L, Arlt H, Harper D, Liu F, Majid T, Patel V, Lengauer C, Garcia-Echeverria C, Zhang B, Cheng H, Dorsch M, Huang SA. Gao Q, et al. Among authors: czechtizky w. J Biol Chem. 2013 Oct 18;288(42):30125-30138. doi: 10.1074/jbc.M113.473348. Epub 2013 Sep 3. J Biol Chem. 2013. PMID: 24003220 Free PMC article.

2

Identification of high-affinity P2Y₁₂ antagonists based on a phenylpyrazole glutamic acid piperazine backbone.

Zech G, Hessler G, Evers A, Weiss T, Florian P, Just M, Czech J, Czechtizky W, Görlitzer J, Ruf S, Kohlmann M, Nazaré M. Zech G, et al. Among authors: czechtizky w. J Med Chem. 2012 Oct 25;55(20):8615-29. doi: 10.1021/jm300771j. Epub 2012 Oct 4. J Med Chem. 2012. PMID: 22984835

3

Sulfamide as Zinc Binding Motif in Small Molecule Inhibitors of Activated Thrombin Activatable Fibrinolysis Inhibitor (TAFIa).

Halland N, Czech J, Czechtizky W, Evers A, Follmann M, Kohlmann M, Schreuder HA, Kallus C. Halland N, et al. Among authors: czechtizky w. J Med Chem. 2016 Oct 27;59(20):9567-9573. doi: 10.1021/acs.jmedchem.6b01276. Epub 2016 Oct 17. J Med Chem. 2016. PMID: 27749053

4

Discovery and pharmacological characterization of a novel small molecule inhibitor of phosphatidylinositol-5-phosphate 4-kinase, type II, beta.

Voss MD, Czechtizky W, Li Z, Rudolph C, Petry S, Brummerhop H, Langer T, Schiffer A, Schaefer HL. Voss MD, et al. Among authors: czechtizky w. Biochem Biophys Res Commun. 2014 Jul 4;449(3):327-31. doi: 10.1016/j.bbrc.2014.05.024. Epub 2014 May 15. Biochem Biophys Res Commun. 2014. PMID: 24845568

5

Synthesis and Modular Reactivity of Pyrazole 5-Trifluoroborates: Intermediates for the Preparation of Fully Functionalized Pyrazoles.

Fricero P, Bialy L, Brown AW, Czechtizky W, Méndez M, Harrity JP. Fricero P, et al. Among authors: czechtizky w. J Org Chem. 2017 Feb 3;82(3):1688-1696. doi: 10.1021/acs.joc.6b02847. Epub 2017 Jan 20. J Org Chem. 2017. PMID: 28081596 Free article.

6

Discovery of a potent, selective, and orally bioavailable histamine H3 receptor antagonist SAR110068 for the treatment of sleep-wake disorders.

Gao Z, Hurst WJ, Czechtizky W, Francon D, Griebel G, Nagorny R, Pichat P, Schwink L, Stengelin S, Hendrix JA, George PG. Gao Z, et al. Among authors: czechtizky w. Bioorg Med Chem Lett. 2013 Nov 15;23(22):6141-5. doi: 10.1016/j.bmcl.2013.09.006. Epub 2013 Sep 8. Bioorg Med Chem Lett. 2013. PMID: 24076172

7

Integrated Synthesis and Testing of Substituted Xanthine Based DPP4 Inhibitors: Application to Drug Discovery.

Czechtizky W, Dedio J, Desai B, Dixon K, Farrant E, Feng Q, Morgan T, Parry DM, Ramjee MK, Selway CN, Schmidt T, Tarver GJ, Wright AG. Czechtizky W, et al. ACS Med Chem Lett. 2013 Jun 10;4(8):768-72. doi: 10.1021/ml400171b. eCollection 2013 Aug 8. ACS Med Chem Lett. 2013. PMID: 24900744 Free PMC article.

8

Identification and profiling of 3,5-dimethyl-isoxazole-4-carboxylic acid [2-methyl-4-((2S,3'S)-2-methyl-[1,3']bipyrrolidinyl-1'-yl)phenyl] amide as histamine H(3) receptor antagonist for the treatment of depression.

Gao Z, Hurst WJ, Czechtizky W, Hall D, Moindrot N, Nagorny R, Pichat P, Stefany D, Hendrix JA, George PG. Gao Z, et al. Among authors: czechtizky w. Bioorg Med Chem Lett. 2013 Dec 1;23(23):6269-73. doi: 10.1016/j.bmcl.2013.09.081. Epub 2013 Oct 3. Bioorg Med Chem Lett. 2013. PMID: 24139584

9

Discovery of aryl ureas and aryl amides as potent and selective histamine H3 receptor antagonists for the treatment of obesity (part I).

Gao Z, Hurst WJ, Guillot E, Czechtizky W, Lukasczyk U, Nagorny R, Pruniaux MP, Schwink L, Sanchez JA, Stengelin S, Tang L, Winkler I, Hendrix JA, George PG. Gao Z, et al. Among authors: czechtizky w. Bioorg Med Chem Lett. 2013 Jun 1;23(11):3416-20. doi: 10.1016/j.bmcl.2013.03.080. Epub 2013 Mar 29. Bioorg Med Chem Lett. 2013. PMID: 23591110

10

Novel Small Molecule Inhibitors of Activated Thrombin Activatable Fibrinolysis Inhibitor (TAFIa) from Natural Product Anabaenopeptin.

Halland N, Brönstrup M, Czech J, Czechtizky W, Evers A, Follmann M, Kohlmann M, Schiell M, Kurz M, Schreuder HA, Kallus C. Halland N, et al. Among authors: czechtizky w. J Med Chem. 2015 Jun 11;58(11):4839-44. doi: 10.1021/jm501840b. Epub 2015 May 20. J Med Chem. 2015. PMID: 25990761

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