Patel RC - Search Results

1

The PKR activator, PACT, becomes a PKR inhibitor during HIV-1 replication.

Clerzius G, Shaw E, Daher A, Burugu S, Gélinas JF, Ear T, Sinck L, Routy JP, Mouland AJ, Patel RC, Gatignol A. Clerzius G, et al. Among authors: patel rc. Retrovirology. 2013 Sep 11;10:96. doi: 10.1186/1742-4690-10-96. Retrovirology. 2013. PMID: 24020926 Free PMC article.

2

TRBP control of PACT-induced phosphorylation of protein kinase R is reversed by stress.

Daher A, Laraki G, Singh M, Melendez-Peña CE, Bannwarth S, Peters AH, Meurs EF, Braun RE, Patel RC, Gatignol A. Daher A, et al. Among authors: patel rc. Mol Cell Biol. 2009 Jan;29(1):254-65. doi: 10.1128/MCB.01030-08. Epub 2008 Oct 20. Mol Cell Biol. 2009. PMID: 18936160 Free PMC article.

3

Inhibition of the inflammatory response to stress by targeting interaction between PKR and its cellular activator PACT.

Dabo S, Maillard P, Collados Rodriguez M, Hansen MD, Mazouz S, Bigot DJ, Tible M, Janvier G, Helynck O, Cassonnet P, Jacob Y, Bellalou J, Gatignol A, Patel RC, Hugon J, Munier-Lehmann H, Meurs EF. Dabo S, et al. Among authors: patel rc. Sci Rep. 2017 Nov 23;7(1):16129. doi: 10.1038/s41598-017-16089-8. Sci Rep. 2017. PMID: 29170442 Free PMC article.

4

Increased interaction between PACT molecules in response to stress signals is required for PKR activation.

Singh M, Patel RC. Singh M, et al. Among authors: patel rc. J Cell Biochem. 2012 Aug;113(8):2754-64. doi: 10.1002/jcb.24152. J Cell Biochem. 2012. PMID: 22473766

5

Altered activation of protein kinase PKR and enhanced apoptosis in dystonia cells carrying a mutation in PKR activator protein PACT.

Vaughn LS, Bragg DC, Sharma N, Camargos S, Cardoso F, Patel RC. Vaughn LS, et al. Among authors: patel rc. J Biol Chem. 2015 Sep 11;290(37):22543-57. doi: 10.1074/jbc.M115.669408. Epub 2015 Jul 31. J Biol Chem. 2015. PMID: 26231208 Free PMC article.

6

Stress-induced phosphorylation of PACT reduces its interaction with TRBP and leads to PKR activation.

Singh M, Castillo D, Patel CV, Patel RC. Singh M, et al. Among authors: patel rc, patel cv. Biochemistry. 2011 May 31;50(21):4550-60. doi: 10.1021/bi200104h. Epub 2011 May 6. Biochemistry. 2011. PMID: 21526770

7

The carboxy-terminal, M3 motifs of PACT and TRBP have opposite effects on PKR activity.

Gupta V, Huang X, Patel RC. Gupta V, et al. Among authors: patel rc. Virology. 2003 Oct 25;315(2):283-91. doi: 10.1016/s0042-6822(03)00589-0. Virology. 2003. PMID: 14585331 Free article.

8

Essential role of PACT-mediated PKR activation in tunicamycin-induced apoptosis.

Singh M, Fowlkes V, Handy I, Patel CV, Patel RC. Singh M, et al. Among authors: patel rc, patel cv. J Mol Biol. 2009 Jan 16;385(2):457-68. doi: 10.1016/j.jmb.2008.10.068. Epub 2008 Nov 5. J Mol Biol. 2009. PMID: 19007793 Free PMC article.

9

PACT, a protein activator of the interferon-induced protein kinase, PKR.

Patel RC, Sen GC. Patel RC, et al. EMBO J. 1998 Aug 3;17(15):4379-90. doi: 10.1093/emboj/17.15.4379. EMBO J. 1998. PMID: 9687506 Free PMC article.

10

Dystonia 16 (DYT16) mutations in PACT cause dysregulated PKR activation and eIF2α signaling leading to a compromised stress response.

Burnett SB, Vaughn LS, Sharma N, Kulkarni R, Patel RC. Burnett SB, et al. Among authors: patel rc. Neurobiol Dis. 2020 Dec;146:105135. doi: 10.1016/j.nbd.2020.105135. Epub 2020 Oct 10. Neurobiol Dis. 2020. PMID: 33049316 Free article.

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