Chandler DS - Search Results

1

Stress-induced isoforms of MDM2 and MDM4 correlate with high-grade disease and an altered splicing network in pediatric rhabdomyosarcoma.

Jacob AG, O'Brien D, Singh RK, Comiskey DF Jr, Littleton RM, Mohammad F, Gladman JT, Widmann MC, Jeyaraj SC, Bolinger C, Anderson JR, Barkauskas DA, Boris-Lawrie K, Chandler DS. Jacob AG, et al. Among authors: chandler ds. Neoplasia. 2013 Sep;15(9):1049-63. doi: 10.1593/neo.13286. Neoplasia. 2013. PMID: 24027430 Free PMC article.

2

Genotoxic stress induces coordinately regulated alternative splicing of the p53 modulators MDM2 and MDM4.

Chandler DS, Singh RK, Caldwell LC, Bitler JL, Lozano G. Chandler DS, et al. Cancer Res. 2006 Oct 1;66(19):9502-8. doi: 10.1158/0008-5472.CAN-05-4271. Cancer Res. 2006. PMID: 17018606

3

NF-kappaB-YY1-miR-29 regulatory circuitry in skeletal myogenesis and rhabdomyosarcoma.

Wang H, Garzon R, Sun H, Ladner KJ, Singh R, Dahlman J, Cheng A, Hall BM, Qualman SJ, Chandler DS, Croce CM, Guttridge DC. Wang H, et al. Among authors: chandler ds. Cancer Cell. 2008 Nov 4;14(5):369-81. doi: 10.1016/j.ccr.2008.10.006. Cancer Cell. 2008. PMID: 18977326 Free PMC article.

4

MDM2 and MDM4 splicing: an integral part of the cancer spliceome.

Jeyaraj S, O'Brien DM, Chandler DS. Jeyaraj S, et al. Among authors: chandler ds. Front Biosci (Landmark Ed). 2009 Jan 1;14(7):2647-56. doi: 10.2741/3402. Front Biosci (Landmark Ed). 2009. PMID: 19273224 Free article. Review.

5

Conserved sequences in the final intron of MDM2 are essential for the regulation of alternative splicing of MDM2 in response to stress.

Singh RK, Tapia-Santos A, Bebee TW, Chandler DS. Singh RK, et al. Among authors: chandler ds. Exp Cell Res. 2009 Nov 15;315(19):3419-32. doi: 10.1016/j.yexcr.2009.07.017. Epub 2009 Jul 21. Exp Cell Res. 2009. PMID: 19631207

6

Intron 7 conserved sequence elements regulate the splicing of the SMN genes.

Gladman JT, Chandler DS. Gladman JT, et al. Among authors: chandler ds. Hum Genet. 2009 Dec;126(6):833-41. doi: 10.1007/s00439-009-0733-7. Hum Genet. 2009. PMID: 19701774 Free PMC article.

7

Splicing of the Survival Motor Neuron genes and implications for treatment of SMA.

Bebee TW, Gladman JT, Chandler DS. Bebee TW, et al. Among authors: chandler ds. Front Biosci (Landmark Ed). 2010 Jun 1;15(3):1191-1204. doi: 10.2741/3670. Front Biosci (Landmark Ed). 2010. PMID: 20515750 Free PMC article. Review.

8

A humanized Smn gene containing the SMN2 nucleotide alteration in exon 7 mimics SMN2 splicing and the SMA disease phenotype.

Gladman JT, Bebee TW, Edwards C, Wang X, Sahenk Z, Rich MM, Chandler DS. Gladman JT, et al. Among authors: chandler ds. Hum Mol Genet. 2010 Nov 1;19(21):4239-52. doi: 10.1093/hmg/ddq343. Epub 2010 Aug 12. Hum Mol Genet. 2010. PMID: 20705738 Free PMC article.

9

Generation of a tamoxifen inducible SMN mouse for temporal SMN replacement.

Bebee TW, Gladman JT, Chandler DS. Bebee TW, et al. Among authors: chandler ds. Genesis. 2011 Dec;49(12):927-34. doi: 10.1002/dvg.20764. Epub 2011 Aug 24. Genesis. 2011. PMID: 21538807

10

Modeling the human MTM1 p.R69C mutation in murine Mtm1 results in exon 4 skipping and a less severe myotubular myopathy phenotype.

Pierson CR, Dulin-Smith AN, Durban AN, Marshall ML, Marshall JT, Snyder AD, Naiyer N, Gladman JT, Chandler DS, Lawlor MW, Buj-Bello A, Dowling JJ, Beggs AH. Pierson CR, et al. Among authors: chandler ds. Hum Mol Genet. 2012 Feb 15;21(4):811-25. doi: 10.1093/hmg/ddr512. Epub 2011 Nov 7. Hum Mol Genet. 2012. PMID: 22068590 Free PMC article.

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