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Familial short stature is associated with a novel dominant-negative heterozygous insulin-like growth factor 1 receptor (IGF1R) mutation.
Kawashima Y, Hakuno F, Okada S, Hotsubo T, Kinoshita T, Fujimoto M, Nishimura R, Fukushima T, Hanaki K, Takahashi S, Kanzaki S. Kawashima Y, et al. Among authors: fukushima t. Clin Endocrinol (Oxf). 2014 Aug;81(2):312-4. doi: 10.1111/cen.12317. Epub 2013 Sep 30. Clin Endocrinol (Oxf). 2014. PMID: 24033502 No abstract available.
Mutation at cleavage site of insulin-like growth factor receptor in a short-stature child born with intrauterine growth retardation.
Kawashima Y, Kanzaki S, Yang F, Kinoshita T, Hanaki K, Nagaishi J, Ohtsuka Y, Hisatome I, Ninomoya H, Nanba E, Fukushima T, Takahashi S. Kawashima Y, et al. Among authors: fukushima t. J Clin Endocrinol Metab. 2005 Aug;90(8):4679-87. doi: 10.1210/jc.2004-1947. Epub 2005 May 31. J Clin Endocrinol Metab. 2005. PMID: 15928254
Cell proliferation activities on skin fibroblasts from a short child with absence of one copy of the type 1 insulin-like growth factor receptor (IGF1R) gene and a tall child with three copies of the IGF1R gene.
Okubo Y, Siddle K, Firth H, O'Rahilly S, Wilson LC, Willatt L, Fukushima T, Takahashi S, Petry CJ, Saukkonen T, Stanhope R, Dunger DB. Okubo Y, et al. Among authors: fukushima t. J Clin Endocrinol Metab. 2003 Dec;88(12):5981-8. doi: 10.1210/jc.2002-021080. J Clin Endocrinol Metab. 2003. PMID: 14671200
Phosphatidylinositol 3-kinase (PI3K) activity bound to insulin-like growth factor-I (IGF-I) receptor, which is continuously sustained by IGF-I stimulation, is required for IGF-I-induced cell proliferation.
Fukushima T, Nakamura Y, Yamanaka D, Shibano T, Chida K, Minami S, Asano T, Hakuno F, Takahashi S. Fukushima T, et al. J Biol Chem. 2012 Aug 24;287(35):29713-21. doi: 10.1074/jbc.M112.393074. Epub 2012 Jul 5. J Biol Chem. 2012. PMID: 22767591 Free PMC article.
The Novel Functions of High-Molecular-Mass Complexes Containing Insulin Receptor Substrates in Mediation and Modulation of Insulin-Like Activities: Emerging Concept of Diverse Functions by IRS-Associated Proteins.
Hakuno F, Fukushima T, Yoneyama Y, Kamei H, Ozoe A, Yoshihara H, Yamanaka D, Shibano T, Sone-Yonezawa M, Yu BC, Chida K, Takahashi S. Hakuno F, et al. Among authors: fukushima t. Front Endocrinol (Lausanne). 2015 May 26;6:73. doi: 10.3389/fendo.2015.00073. eCollection 2015. Front Endocrinol (Lausanne). 2015. PMID: 26074875 Free PMC article. Review.
2,548 results