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Epigallocatechin-3-gallate, a DYRK1A inhibitor, rescues cognitive deficits in Down syndrome mouse models and in humans.
De la Torre R, De Sola S, Pons M, Duchon A, de Lagran MM, Farré M, Fitó M, Benejam B, Langohr K, Rodriguez J, Pujadas M, Bizot JC, Cuenca A, Janel N, Catuara S, Covas MI, Blehaut H, Herault Y, Delabar JM, Dierssen M. De la Torre R, et al. Among authors: herault y. Mol Nutr Food Res. 2014 Feb;58(2):278-88. doi: 10.1002/mnfr.201300325. Epub 2013 Sep 14. Mol Nutr Food Res. 2014. PMID: 24039182 Clinical Trial.
A new mouse model for the trisomy of the Abcg1-U2af1 region reveals the complexity of the combinatorial genetic code of down syndrome.
Pereira PL, Magnol L, Sahún I, Brault V, Duchon A, Prandini P, Gruart A, Bizot JC, Chadefaux-Vekemans B, Deutsch S, Trovero F, Delgado-García JM, Antonarakis SE, Dierssen M, Herault Y. Pereira PL, et al. Among authors: herault y. Hum Mol Genet. 2009 Dec 15;18(24):4756-69. doi: 10.1093/hmg/ddp438. Epub 2009 Sep 26. Hum Mol Genet. 2009. PMID: 19783846 Free PMC article.
DYRK1A, a novel determinant of the methionine-homocysteine cycle in different mouse models overexpressing this Down-syndrome-associated kinase.
Noll C, Planque C, Ripoll C, Guedj F, Diez A, Ducros V, Belin N, Duchon A, Paul JL, Badel A, de Freminville B, Grattau Y, Bléhaut H, Herault Y, Janel N, Delabar JM. Noll C, et al. Among authors: herault y. PLoS One. 2009 Oct 21;4(10):e7540. doi: 10.1371/journal.pone.0007540. PLoS One. 2009. PMID: 19844572 Free PMC article.
Down syndrome: from understanding the neurobiology to therapy.
Gardiner K, Herault Y, Lott IT, Antonarakis SE, Reeves RH, Dierssen M. Gardiner K, et al. Among authors: herault y. J Neurosci. 2010 Nov 10;30(45):14943-5. doi: 10.1523/JNEUROSCI.3728-10.2010. J Neurosci. 2010. PMID: 21068296 Free PMC article. Review.
DYRK1A: a master regulatory protein controlling brain growth.
Guedj F, Pereira PL, Najas S, Barallobre MJ, Chabert C, Souchet B, Sebrie C, Verney C, Herault Y, Arbones M, Delabar JM. Guedj F, et al. Among authors: herault y. Neurobiol Dis. 2012 Apr;46(1):190-203. doi: 10.1016/j.nbd.2012.01.007. Epub 2012 Jan 26. Neurobiol Dis. 2012. PMID: 22293606
211 results