Hopkins CR - Search Results

1

Reversible inhibitors of regulators of G-protein signaling identified in a high-throughput cell-based calcium signaling assay.

Storaska AJ, Mei JP, Wu M, Li M, Wade SM, Blazer LL, Sjögren B, Hopkins CR, Lindsley CW, Lin Z, Babcock JJ, McManus OB, Neubig RR. Storaska AJ, et al. Among authors: hopkins cr. Cell Signal. 2013 Dec;25(12):2848-55. doi: 10.1016/j.cellsig.2013.09.007. Epub 2013 Sep 14. Cell Signal. 2013. PMID: 24041654 Free PMC article.

2

Synthesis and evaluation of a series of heterobiarylamides that are centrally penetrant metabotropic glutamate receptor 4 (mGluR4) positive allosteric modulators (PAMs).

Engers DW, Niswender CM, Weaver CD, Jadhav S, Menon UN, Zamorano R, Conn PJ, Lindsley CW, Hopkins CR. Engers DW, et al. Among authors: hopkins cr. J Med Chem. 2009 Jul 23;52(14):4115-8. doi: 10.1021/jm9005065. J Med Chem. 2009. PMID: 19469556 Free PMC article.

3

Synthesis and SAR of a novel positive allosteric modulator (PAM) of the metabotropic glutamate receptor 4 (mGluR4).

Williams R, Johnson KA, Gentry PR, Niswender CM, Weaver CD, Conn PJ, Lindsley CW, Hopkins CR. Williams R, et al. Among authors: hopkins cr. Bioorg Med Chem Lett. 2009 Sep 1;19(17):4967-70. doi: 10.1016/j.bmcl.2009.07.072. Epub 2009 Jul 18. Bioorg Med Chem Lett. 2009. PMID: 19640716 Free PMC article.

4

Recent progress in the development of mGluR4 positive allosteric modulators for the treatment of Parkinson's disease.

Lindsley CW, Niswender CM, Engers DW, Hopkins CR. Lindsley CW, et al. Among authors: hopkins cr. Curr Top Med Chem. 2009;9(10):949-63. Curr Top Med Chem. 2009. PMID: 19754407 Review.

5

Chemical lead optimization of a pan G(q) mAChR M(1), M(3), M(5) positive allosteric modulator (PAM) lead. Part I: Development of the first highly selective M(5) PAM.

Bridges TM, Kennedy JP, Cho HP, Breininger ML, Gentry PR, Hopkins CR, Conn PJ, Lindsley CW. Bridges TM, et al. Among authors: hopkins cr. Bioorg Med Chem Lett. 2010 Jan 15;20(2):558-62. doi: 10.1016/j.bmcl.2009.11.089. Epub 2009 Nov 22. Bioorg Med Chem Lett. 2010. PMID: 20004578 Free PMC article.

6

In vivo structure-activity relationship study of dorsomorphin analogues identifies selective VEGF and BMP inhibitors.

Hao J, Ho JN, Lewis JA, Karim KA, Daniels RN, Gentry PR, Hopkins CR, Lindsley CW, Hong CC. Hao J, et al. Among authors: hopkins cr. ACS Chem Biol. 2010 Feb 19;5(2):245-53. doi: 10.1021/cb9002865. ACS Chem Biol. 2010. PMID: 20020776 Free PMC article.

7

mGluR4-positive allosteric modulation as potential treatment for Parkinson's disease.

Hopkins CR, Lindsley CW, Niswender CM. Hopkins CR, et al. Future Med Chem. 2009 Jun;1(3):501-13. doi: 10.4155/fmc.09.38. Future Med Chem. 2009. PMID: 20161443 Free PMC article. Review.

8

The antipsychotic potential of muscarinic allosteric modulation.

Bridges TM, LeBois EP, Hopkins CR, Wood MR, Jones CK, Conn PJ, Lindsley CW. Bridges TM, et al. Among authors: hopkins cr. Drug News Perspect. 2010 May;23(4):229-40. doi: 10.1358/dnp.2010.23.4.1416977. Drug News Perspect. 2010. PMID: 20520852 Free PMC article. Review.

9

Re-exploration of the PHCCC Scaffold: Discovery of Improved Positive Allosteric Modulators of mGluR4.

Williams R, Zhou Y, Niswender CM, Luo Q, Conn PJ, Lindsley CW, Hopkins CR. Williams R, et al. Among authors: hopkins cr. ACS Chem Neurosci. 2010 Jun 16;1(6):411-419. doi: 10.1021/cn9000318. ACS Chem Neurosci. 2010. PMID: 20582156 Free PMC article.

10

Synthesis of 2,3-diarylsubstituted indazoles utilizing a Suzuki cross-coupling/deprotection/N-arylation sequence.

Salovich JM, Lindsley CW, Hopkins CR. Salovich JM, et al. Among authors: hopkins cr. Tetrahedron Lett. 2010 Jul 21;51(29):3796-3799. doi: 10.1016/j.tetlet.2010.05.060. Tetrahedron Lett. 2010. PMID: 20606711 Free PMC article.

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