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FGF-21/FGF-21 receptor interaction and activation is determined by betaKlotho.
Kharitonenkov A, Dunbar JD, Bina HA, Bright S, Moyers JS, Zhang C, Ding L, Micanovic R, Mehrbod SF, Knierman MD, Hale JE, Coskun T, Shanafelt AB. Kharitonenkov A, et al. Among authors: coskun t. J Cell Physiol. 2008 Apr;215(1):1-7. doi: 10.1002/jcp.21357. J Cell Physiol. 2008. PMID: 18064602
Fibroblast growth factor 21 corrects obesity in mice.
Coskun T, Bina HA, Schneider MA, Dunbar JD, Hu CC, Chen Y, Moller DE, Kharitonenkov A. Coskun T, et al. Endocrinology. 2008 Dec;149(12):6018-27. doi: 10.1210/en.2008-0816. Epub 2008 Aug 7. Endocrinology. 2008. PMID: 18687777
Fundamentals of FGF19 & FGF21 action in vitro and in vivo.
Adams AC, Coskun T, Rovira AR, Schneider MA, Raches DW, Micanovic R, Bina HA, Dunbar JD, Kharitonenkov A. Adams AC, et al. Among authors: coskun t. PLoS One. 2012;7(5):e38438. doi: 10.1371/journal.pone.0038438. Epub 2012 May 31. PLoS One. 2012. PMID: 22675463 Free PMC article.
FGF21 requires βklotho to act in vivo.
Adams AC, Cheng CC, Coskun T, Kharitonenkov A. Adams AC, et al. Among authors: coskun t. PLoS One. 2012;7(11):e49977. doi: 10.1371/journal.pone.0049977. Epub 2012 Nov 27. PLoS One. 2012. PMID: 23209629 Free PMC article.
Rational design of a fibroblast growth factor 21-based clinical candidate, LY2405319.
Kharitonenkov A, Beals JM, Micanovic R, Strifler BA, Rathnachalam R, Wroblewski VJ, Li S, Koester A, Ford AM, Coskun T, Dunbar JD, Cheng CC, Frye CC, Bumol TF, Moller DE. Kharitonenkov A, et al. Among authors: coskun t. PLoS One. 2013;8(3):e58575. doi: 10.1371/journal.pone.0058575. Epub 2013 Mar 11. PLoS One. 2013. PMID: 23536797 Free PMC article.
Photoperiodic regulation of FGF21 production in the Siberian hamster.
Samms RJ, Fowler MJ, Cooper S, Emmerson P, Coskun T, Adams AC, Kharitonenkov A, Tsintzas K, Ebling FJ. Samms RJ, et al. Among authors: coskun t. Horm Behav. 2014 Jun;66(1):180-5. doi: 10.1016/j.yhbeh.2014.03.013. Horm Behav. 2014. PMID: 24909854
411 results