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Chimeric anti-CD14 IGG2/4 Hybrid antibodies for therapeutic intervention in pig and human models of inflammation.
Lau C, Gunnarsen KS, Høydahl LS, Andersen JT, Berntzen G, Pharo A, Lindstad JK, Ludviksen JK, Brekke OL, Barratt-Due A, Nielsen EW, Stokes CR, Espevik T, Sandlie I, Mollnes TE. Lau C, et al. Among authors: pharo a. J Immunol. 2013 Nov 1;191(9):4769-77. doi: 10.4049/jimmunol.1301653. Epub 2013 Sep 23. J Immunol. 2013. PMID: 24062486 Free PMC article.
Human genetic deficiencies reveal the roles of complement in the inflammatory network: lessons from nature.
Lappegård KT, Christiansen D, Pharo A, Thorgersen EB, Hellerud BC, Lindstad J, Nielsen EW, Bergseth G, Fadnes D, Abrahamsen TG, Høiby EA, Schejbel L, Garred P, Lambris JD, Harboe M, Mollnes TE. Lappegård KT, et al. Among authors: pharo a. Proc Natl Acad Sci U S A. 2009 Sep 15;106(37):15861-6. doi: 10.1073/pnas.0903613106. Epub 2009 Aug 26. Proc Natl Acad Sci U S A. 2009. PMID: 19717455 Free PMC article.
CD14 inhibition efficiently attenuates early inflammatory and hemostatic responses in Escherichia coli sepsis in pigs.
Thorgersen EB, Hellerud BC, Nielsen EW, Barratt-Due A, Fure H, Lindstad JK, Pharo A, Fosse E, Tønnessen TI, Johansen HT, Castellheim A, Mollnes TE. Thorgersen EB, et al. Among authors: pharo a. FASEB J. 2010 Mar;24(3):712-22. doi: 10.1096/fj.09-140798. Epub 2009 Oct 19. FASEB J. 2010. PMID: 19841036 Free PMC article.
The aim of this study was to investigate the effects of inhibiting CD14, a key upstream innate immunity molecule, on the early inflammatory and hemostatic responses in a pig model of gram-negative sepsis. ...B., Hellerud, B. C., Nielsen, E. W., Barratt-Due, A …
The aim of this study was to investigate the effects of inhibiting CD14, a key upstream innate immunity molecule, on the early inflam …
Neisseria meningitidis and Escherichia coli are protected from leukocyte phagocytosis by binding to erythrocyte complement receptor 1 in human blood.
Brekke OL, Hellerud BC, Christiansen D, Fure H, Castellheim A, Nielsen EW, Pharo A, Lindstad JK, Bergseth G, Leslie G, Lambris JD, Brandtzaeg P, Mollnes TE. Brekke OL, et al. Among authors: pharo a. Mol Immunol. 2011 Sep;48(15-16):2159-69. doi: 10.1016/j.molimm.2011.07.011. Epub 2011 Aug 11. Mol Immunol. 2011. PMID: 21839519 Free PMC article.
48 results