Loss of acetylation at Lys16 and trimethylation at Lys20 of histone H4 is a common hallmark of human cancer.
Fraga MF, Ballestar E, Villar-Garea A, Boix-Chornet M, Espada J, Schotta G, Bonaldi T, Haydon C, Ropero S, Petrie K, Iyer NG, Pérez-Rosado A, Calvo E, Lopez JA, Cano A, Calasanz MJ, Colomer D, Piris MA, Ahn N, Imhof A, Caldas C, Jenuwein T, Esteller M.
Fraga MF, et al. Among authors: imhof a.
Nat Genet. 2005 Apr;37(4):391-400. doi: 10.1038/ng1531. Epub 2005 Mar 13.
Nat Genet. 2005.
PMID: 15765097