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Mitochondria are required for pro-ageing features of the senescent phenotype.
Correia-Melo C, Marques FD, Anderson R, Hewitt G, Hewitt R, Cole J, Carroll BM, Miwa S, Birch J, Merz A, Rushton MD, Charles M, Jurk D, Tait SW, Czapiewski R, Greaves L, Nelson G, Bohlooly-Y M, Rodriguez-Cuenca S, Vidal-Puig A, Mann D, Saretzki G, Quarato G, Green DR, Adams PD, von Zglinicki T, Korolchuk VI, Passos JF. Correia-Melo C, et al. Among authors: nelson g. EMBO J. 2016 Apr 1;35(7):724-42. doi: 10.15252/embj.201592862. Epub 2016 Feb 4. EMBO J. 2016. PMID: 26848154 Free PMC article.
Feedback between p21 and reactive oxygen production is necessary for cell senescence.
Passos JF, Nelson G, Wang C, Richter T, Simillion C, Proctor CJ, Miwa S, Olijslagers S, Hallinan J, Wipat A, Saretzki G, Rudolph KL, Kirkwood TB, von Zglinicki T. Passos JF, et al. Among authors: nelson g. Mol Syst Biol. 2010;6:347. doi: 10.1038/msb.2010.5. Epub 2010 Feb 16. Mol Syst Biol. 2010. PMID: 20160708 Free PMC article.
A senescent cell bystander effect: senescence-induced senescence.
Nelson G, Wordsworth J, Wang C, Jurk D, Lawless C, Martin-Ruiz C, von Zglinicki T. Nelson G, et al. Aging Cell. 2012 Apr;11(2):345-9. doi: 10.1111/j.1474-9726.2012.00795.x. Epub 2012 Feb 9. Aging Cell. 2012. PMID: 22321662 Free PMC article.
Monitoring DNA damage during cell senescence.
Nelson G, von Zglinicki T. Nelson G, et al. Methods Mol Biol. 2013;965:197-213. doi: 10.1007/978-1-62703-239-1_13. Methods Mol Biol. 2013. PMID: 23296660
1,907 results