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P7170: A Novel Molecule with Unique Profile of mTORC1/C2 and Activin Receptor-like Kinase 1 Inhibition Leading to Antitumor and Antiangiogenic Activity.
Jalota-Badhwar A, Bhatia DR, Boreddy S, Joshi A, Venkatraman M, Desai N, Chaudhari S, Bose J, Kolla LS, Deore V, Yewalkar N, Kumar S, Sharma R, Damre A, More A, Sharma S, Agarwal VR. Jalota-Badhwar A, et al. Among authors: deore v. Mol Cancer Ther. 2015 May;14(5):1095-106. doi: 10.1158/1535-7163.MCT-14-0486. Epub 2015 Feb 19. Mol Cancer Ther. 2015. PMID: 25700704
A novel mTOR inhibitor is efficacious in a murine model of colitis.
Bhonde MR, Gupte RD, Dadarkar SD, Jadhav MG, Tannu AA, Bhatt P, Bhatia DR, Desai NK, Deore V, Yewalkar N, Vishwakarma RA, Sharma S, Kumar S, Dagia NM. Bhonde MR, et al. Among authors: deore v. Am J Physiol Gastrointest Liver Physiol. 2008 Dec;295(6):G1237-45. doi: 10.1152/ajpgi.90537.2008. Epub 2008 Oct 16. Am J Physiol Gastrointest Liver Physiol. 2008. PMID: 18927209 Free article.
Synthesis and therapeutic evaluation of pyridyl based novel mTOR inhibitors.
Deore V, Yewalkar N, Bhatia D, Desai N, Gupte RD, Dadarkar SS, Jadhav MG, Tannu AA, Bhatt P, Nemmani KV, Vishwakarma RA, Sharma S, Roychowdhury A, Dagia NM, Bhonde MR, Kumar S. Deore V, et al. Bioorg Med Chem Lett. 2009 Jun 1;19(11):2949-52. doi: 10.1016/j.bmcl.2009.04.055. Epub 2009 Apr 18. Bioorg Med Chem Lett. 2009. PMID: 19409777
P7170, a novel inhibitor of mTORC1/mTORC2 and Activin receptor-like Kinase 1 (ALK1) inhibits the growth of non small cell lung cancer.
Venkatesha VA, Joshi A, Venkataraman M, Sonawane V, Bhatia D, Tannu P, Bose J, Choudhari S, Srivastava A, Pandey PK, Lad VJ, Sangana R, Ahmed T, Damre A, Deore V, Sahu B, Kumar S, Sharma S, Agarwal VR. Venkatesha VA, et al. Among authors: deore v. Mol Cancer. 2014 Dec 2;13:259. doi: 10.1186/1476-4598-13-259. Mol Cancer. 2014. PMID: 25466244 Free PMC article.
15 results