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Unbiased screening of marine sponge extracts for anti-inflammatory agents combined with chemical genomics identifies girolline as an inhibitor of protein synthesis.
Fung SY, Sofiyev V, Schneiderman J, Hirschfeld AF, Victor RE, Woods K, Piotrowski JS, Deshpande R, Li SC, de Voogd NJ, Myers CL, Boone C, Andersen RJ, Turvey SE. Fung SY, et al. Among authors: deshpande r. ACS Chem Biol. 2014 Jan 17;9(1):247-57. doi: 10.1021/cb400740c. Epub 2013 Oct 29. ACS Chem Biol. 2014. PMID: 24117378 Free PMC article.
Functional annotation of chemical libraries across diverse biological processes.
Piotrowski JS, Li SC, Deshpande R, Simpkins SW, Nelson J, Yashiroda Y, Barber JM, Safizadeh H, Wilson E, Okada H, Gebre AA, Kubo K, Torres NP, LeBlanc MA, Andrusiak K, Okamoto R, Yoshimura M, DeRango-Adem E, van Leeuwen J, Shirahige K, Baryshnikova A, Brown GW, Hirano H, Costanzo M, Andrews B, Ohya Y, Osada H, Yoshida M, Myers CL, Boone C. Piotrowski JS, et al. Among authors: deshpande r. Nat Chem Biol. 2017 Sep;13(9):982-993. doi: 10.1038/nchembio.2436. Epub 2017 Jul 24. Nat Chem Biol. 2017. PMID: 28759014 Free PMC article.
Plant-derived antifungal agent poacic acid targets β-1,3-glucan.
Piotrowski JS, Okada H, Lu F, Li SC, Hinchman L, Ranjan A, Smith DL, Higbee AJ, Ulbrich A, Coon JJ, Deshpande R, Bukhman YV, McIlwain S, Ong IM, Myers CL, Boone C, Landick R, Ralph J, Kabbage M, Ohya Y. Piotrowski JS, et al. Among authors: deshpande r. Proc Natl Acad Sci U S A. 2015 Mar 24;112(12):E1490-7. doi: 10.1073/pnas.1410400112. Epub 2015 Mar 9. Proc Natl Acad Sci U S A. 2015. PMID: 25775513 Free PMC article.
Forazoline A: marine-derived polyketide with antifungal in vivo efficacy.
Wyche TP, Piotrowski JS, Hou Y, Braun D, Deshpande R, McIlwain S, Ong IM, Myers CL, Guzei IA, Westler WM, Andes DR, Bugni TS. Wyche TP, et al. Among authors: deshpande r. Angew Chem Int Ed Engl. 2014 Oct 20;53(43):11583-6. doi: 10.1002/anie.201405990. Epub 2014 Sep 4. Angew Chem Int Ed Engl. 2014. PMID: 25197007 Free PMC article.
Predicting bioprocess targets of chemical compounds through integration of chemical-genetic and genetic interactions.
Simpkins SW, Nelson J, Deshpande R, Li SC, Piotrowski JS, Wilson EH, Gebre AA, Safizadeh H, Okamoto R, Yoshimura M, Costanzo M, Yashiroda Y, Ohya Y, Osada H, Yoshida M, Boone C, Myers CL. Simpkins SW, et al. Among authors: deshpande r. PLoS Comput Biol. 2018 Oct 30;14(10):e1006532. doi: 10.1371/journal.pcbi.1006532. eCollection 2018 Oct. PLoS Comput Biol. 2018. PMID: 30376562 Free PMC article.
Errata: Functional annotation of chemical libraries across diverse biological processes.
Piotrowski JS, Li SC, Deshpande R, Simpkins SW, Nelson J, Yashiroda Y, Barber JM, Safizadeh H, Wilson E, Okada H, Gebre AA, Kubo K, Torres NP, LeBlanc MA, Andrusiak K, Okamoto R, Yoshimura M, DeRango-Adem E, van Leeuwen J, Shirahige K, Baryshnikova A, Brown GW, Hirano H, Costanzo M, Andrews B, Ohya Y, Osada H, Yoshida M, Myers CL, Boone C. Piotrowski JS, et al. Among authors: deshpande r. Nat Chem Biol. 2017 Nov 21;13(12):1286. doi: 10.1038/nchembio1217-1286b. Nat Chem Biol. 2017. PMID: 29161244
Errata: Functional annotation of chemical libraries across diverse biological processes.
Piotrowski JS, Li SC, Deshpande R, Simpkins SW, Nelson J, Yashiroda Y, Barber JM, Safizadeh H, Wilson E, Okada H, Gebre AA, Kubo K, Torres NP, LeBlanc MA, Andrusiak K, Okamoto R, Yoshimura M, DeRango-Adem E, van Leeuwen J, Shirahige K, Baryshnikova A, Brown GW, Hirano H, Costanzo M, Andrews B, Ohya Y, Osada H, Yoshida M, Myers CL, Boone C. Piotrowski JS, et al. Among authors: deshpande r. Nat Chem Biol. 2017 Nov 21;13(12):1286. doi: 10.1038/nchembio1217-1286a. Nat Chem Biol. 2017. PMID: 29161247
657 results