Xu S - Search Results

1

Design, synthesis, and biological evaluation of 2-oxo-3,4-dihydropyrimido[4,5-d]pyrimidinyl derivatives as new irreversible epidermal growth factor receptor inhibitors with improved pharmacokinetic properties.

Xu S, Xu T, Zhang L, Zhang Z, Luo J, Liu Y, Lu X, Tu Z, Ren X, Ding K. Xu S, et al. Among authors: xu t. J Med Chem. 2013 Nov 14;56(21):8803-13. doi: 10.1021/jm4012388. Epub 2013 Oct 31. J Med Chem. 2013. PMID: 24124898

2

Design, synthesis, and biological evaluation of novel conformationally constrained inhibitors targeting epidermal growth factor receptor threonine⁷⁹⁰ → methionine⁷⁹⁰ mutant.

Chang S, Zhang L, Xu S, Luo J, Lu X, Zhang Z, Xu T, Liu Y, Tu Z, Xu Y, Ren X, Geng M, Ding J, Pei D, Ding K. Chang S, et al. Among authors: xu s, xu t, xu y. J Med Chem. 2012 Mar 22;55(6):2711-23. doi: 10.1021/jm201591k. Epub 2012 Mar 1. J Med Chem. 2012. PMID: 22339342

3

1-Phenyl-4-benzoyl-1H-1,2,3-triazoles as orally bioavailable transcriptional function suppressors of estrogen-related receptor α.

Xu S, Zhuang X, Pan X, Zhang Z, Duan L, Liu Y, Zhang L, Ren X, Ding K. Xu S, et al. J Med Chem. 2013 Jun 13;56(11):4631-40. doi: 10.1021/jm4003928. Epub 2013 May 24. J Med Chem. 2013. PMID: 23656512

4

Pyrimido[4,5-d]pyrimidin-4(1H)-one derivatives as selective inhibitors of EGFR threonine790 to methionine790 (T790M) mutants.

Xu T, Zhang L, Xu S, Yang CY, Luo J, Ding F, Lu X, Liu Y, Tu Z, Li S, Pei D, Cai Q, Li H, Ren X, Wang S, Ding K. Xu T, et al. Among authors: xu s. Angew Chem Int Ed Engl. 2013 Aug 5;52(32):8387-90. doi: 10.1002/anie.201302313. Epub 2013 Jun 26. Angew Chem Int Ed Engl. 2013. PMID: 23804305 Free article. No abstract available.

5

1-Benzyl-4-phenyl-1H-1,2,3-triazoles improve the transcriptional functions of estrogen-related receptor γ and promote the browning of white adipose.

Xu S, Mao L, Ding P, Zhuang X, Zhou Y, Yu L, Liu Y, Nie T, Xu T, Xu Y, Liu J, Smaill J, Ren X, Wu D, Ding K. Xu S, et al. Among authors: xu t, xu y. Bioorg Med Chem. 2015 Jul 1;23(13):3751-60. doi: 10.1016/j.bmc.2015.03.082. Epub 2015 Apr 9. Bioorg Med Chem. 2015. PMID: 25910584

6

Design of the First-in-Class, Highly Potent Irreversible Inhibitor Targeting the Menin-MLL Protein-Protein Interaction.

Xu S, Aguilar A, Xu T, Zheng K, Huang L, Stuckey J, Chinnaswamy K, Bernard D, Fernández-Salas E, Liu L, Wang M, McEachern D, Przybranowski S, Foster C, Wang S. Xu S, et al. Among authors: xu t. Angew Chem Int Ed Engl. 2018 Feb 5;57(6):1601-1605. doi: 10.1002/anie.201711828. Epub 2018 Jan 15. Angew Chem Int Ed Engl. 2018. PMID: 29284071 Free article.

7

Structure-Based Discovery of M-89 as a Highly Potent Inhibitor of the Menin-Mixed Lineage Leukemia (Menin-MLL) Protein-Protein Interaction.

Aguilar A, Zheng K, Xu T, Xu S, Huang L, Fernandez-Salas E, Liu L, Bernard D, Harvey KP, Foster C, McEachern D, Stuckey J, Chinnaswamy K, Delproposto J, Kampf JW, Wang S. Aguilar A, et al. Among authors: xu s, xu t. J Med Chem. 2019 Jul 11;62(13):6015-6034. doi: 10.1021/acs.jmedchem.9b00021. Epub 2019 Jun 22. J Med Chem. 2019. PMID: 31244110 Free PMC article.

8

Tyrosine Kinase 2 (TYK2) Allosteric Inhibitors To Treat Autoimmune Diseases.

Chang Y, Xu S, Ding K. Chang Y, et al. Among authors: xu s. J Med Chem. 2019 Oct 24;62(20):8951-8952. doi: 10.1021/acs.jmedchem.9b01612. Epub 2019 Oct 11. J Med Chem. 2019. PMID: 31603320

9

Discovery of M-808 as a Highly Potent, Covalent, Small-Molecule Inhibitor of the Menin-MLL Interaction with Strong In Vivo Antitumor Activity.

Xu S, Aguilar A, Huang L, Xu T, Zheng K, McEachern D, Przybranowski S, Foster C, Zawacki K, Liu Z, Chinnaswamy K, Stuckey J, Wang S. Xu S, et al. Among authors: xu t. J Med Chem. 2020 May 14;63(9):4997-5010. doi: 10.1021/acs.jmedchem.0c00547. Epub 2020 Apr 27. J Med Chem. 2020. PMID: 32338903 Free PMC article.

10

Discovery of a potent, selective, and covalent ZAP-70 kinase inhibitor.

Rao D, Li H, Ren X, Sun Y, Wen C, Zheng M, Huang H, Tang W, Xu S. Rao D, et al. Among authors: xu s. Eur J Med Chem. 2021 Jul 5;219:113393. doi: 10.1016/j.ejmech.2021.113393. Epub 2021 Mar 30. Eur J Med Chem. 2021. PMID: 33845236

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