Haraguchi K - Search Results

1

KAY-2-41, a novel nucleoside analogue inhibitor of orthopoxviruses in vitro and in vivo.

Duraffour S, Drillien R, Haraguchi K, Balzarini J, Topalis D, van den Oord JJ, Andrei G, Snoeck R. Duraffour S, et al. Among authors: haraguchi k. Antimicrob Agents Chemother. 2014;58(1):27-37. doi: 10.1128/AAC.01601-13. Epub 2013 Oct 14. Antimicrob Agents Chemother. 2014. PMID: 24126587 Free PMC article.

2

Antiherpesvirus activities of two novel 4'-thiothymidine derivatives, KAY-2-41 and KAH-39-149, are dependent on viral and cellular thymidine kinases.

Coen N, Duraffour S, Haraguchi K, Balzarini J, van den Oord JJ, Snoeck R, Andrei G. Coen N, et al. Among authors: haraguchi k. Antimicrob Agents Chemother. 2014 Aug;58(8):4328-40. doi: 10.1128/AAC.02825-14. Epub 2014 May 12. Antimicrob Agents Chemother. 2014. PMID: 24820089 Free PMC article.

3

Synthesis of 3',4'-difluoro-3'-deoxyribonucleosides and its evaluation of the biological activities: discovery of a novel type of anti-HCV agent 3',4'-difluorocordycepin.

Shimada H, Haraguchi K, Hotta K, Miyaike T, Kitagawa Y, Tanaka H, Kaneda R, Abe H, Shuto S, Mori K, Ueda Y, Kato N, Snoeck R, Andrei G, Balzarini J. Shimada H, et al. Among authors: haraguchi k. Bioorg Med Chem. 2014 Nov 1;22(21):6174-82. doi: 10.1016/j.bmc.2014.08.024. Epub 2014 Sep 17. Bioorg Med Chem. 2014. PMID: 25282652

4

Synthesis and antiviral evaluation of 4'-alkoxy analogues of 9-(beta-D-xylofuranosyl)adenine.

Kubota Y, Ishizaki N, Kaneda Y, Haraguchi K, Odanaka Y, Tanaka H, Kato N, Baba M, Balzarini J. Kubota Y, et al. Among authors: haraguchi k. Antivir Chem Chemother. 2009;19(5):201-12. doi: 10.1177/095632020901900503. Antivir Chem Chemother. 2009. PMID: 19483268 Free article.

5

Anti-human immunodeficiency virus type 1 activity and resistance profile of 2',3'-didehydro-3'-deoxy-4'-ethynylthymidine in vitro.

Nitanda T, Wang X, Kumamoto H, Haraguchi K, Tanaka H, Cheng YC, Baba M. Nitanda T, et al. Among authors: haraguchi k. Antimicrob Agents Chemother. 2005 Aug;49(8):3355-60. doi: 10.1128/AAC.49.8.3355-3360.2005. Antimicrob Agents Chemother. 2005. PMID: 16048947 Free PMC article.

6

Tuning efficiency of the 4-exo-trig cyclization by the electronic effect: ring closure of 3,3-difluoro-4-pentenyl carbon radicals and synthesis of a gem-difluorocyclobutane nucleoside.

Kumamoto H, Kawahigashi S, Wakabayashi H, Nakano T, Miyaike T, Kitagawa Y, Abe H, Ito M, Haraguchi K, Balzarini J, Baba M, Tanaka H. Kumamoto H, et al. Among authors: haraguchi k. Chem Commun (Camb). 2012 Nov 18;48(89):10993-5. doi: 10.1039/c2cc35876j. Chem Commun (Camb). 2012. PMID: 23038212

7

Synthesis of 4'-Ethynyl-2'-deoxy-4'-thioribonucleosides and Discovery of a Highly Potent and Less Toxic NRTI.

Haraguchi K, Shimada H, Kimura K, Akutsu G, Tanaka H, Abe H, Hamasaki T, Baba M, Gullen EA, Dutschman GE, Cheng YC, Balzarini J. Haraguchi K, et al. ACS Med Chem Lett. 2011 Sep 8;2(9):692-697. doi: 10.1021/ml2001054. ACS Med Chem Lett. 2011. PMID: 23795238 Free PMC article.

8

Novel 4'-substituted stavudine analog with improved anti-human immunodeficiency virus activity and decreased cytotoxicity.

Dutschman GE, Grill SP, Gullen EA, Haraguchi K, Takeda S, Tanaka H, Baba M, Cheng YC. Dutschman GE, et al. Among authors: haraguchi k. Antimicrob Agents Chemother. 2004 May;48(5):1640-6. doi: 10.1128/AAC.48.5.1640-1646.2004. Antimicrob Agents Chemother. 2004. PMID: 15105115 Free PMC article.

9

Synthesis and anti-HIV activity of 4'-C-ethynyl-2'-deoxy-4'-thio-nucleosides.

Haraguchi K, Shimada H, Akutsu G, Kimura K, Tanaka H, Hamasaki T, Baba M, Gullen EA, Dutschman GE, Cheng YC, Balzarini J. Haraguchi K, et al. Nucleic Acids Symp Ser (Oxf). 2009;(53):97-8. doi: 10.1093/nass/nrp049. Nucleic Acids Symp Ser (Oxf). 2009. PMID: 19749278

10

4'-Ethynylstavudine (4'-Ed4T) has potent anti-HIV-1 activity with reduced toxicity and shows a unique activity profile against drug-resistant mutants.

Tanaka H, Haraguchi K, Kumamoto H, Baba M, Cheng YC. Tanaka H, et al. Among authors: haraguchi k. Antivir Chem Chemother. 2005;16(4):217-21. doi: 10.1177/095632020501600402. Antivir Chem Chemother. 2005. PMID: 16130520 Free article.

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